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http://hdl.handle.net/11320/16609
Tytuł: | The Spray-Dried Alginate/Gelatin Microparticles with Luliconazole as Mucoadhesive Drug Delivery System |
Autorzy: | Szekalska, Marta Wróblewska, Magdalena Czajkowska-Kośnik, Anna Sosnowska, Katarzyna Misiak, Paweł Wilczewska, Agnieszka Zofia Winnicka, Katarzyna |
Słowa kluczowe: | microparticles sodium alginate gelatin luliconazole spray drying antifungal activity |
Data wydania: | 2023 |
Data dodania: | 5-cze-2024 |
Źródło: | Materials, Vol. 16, Iss. 1, 2023, p. 403 |
Abstrakt: | Candida species are opportunistic fungi, which are primary causative agents of vulvovaginal candidiasis. The cure of candidiasis is difficult, lengthy, and associated with the fungi resistivity. Therefore, the research for novel active substances and unconventional drug delivery systems providing effective and safe treatment is still an active subject. Microparticles, as multicompartment dosage forms due to larger areas, provide short passage of drug diffusion, which might improve drug therapeutic efficiency. Sodium alginate is a natural polymer from a polysaccharide group, possessing swelling, mucoadhesive, and gelling properties. Gelatin A is a natural high-molecular-weight polypeptide obtained from porcine collagen. The purpose of this study was to prepare microparticles by the spray-drying of alginate/gelatin polyelectrolyte complex mixture, with a novel antifungal drug—luliconazole. In the next stage of research, the effect of gelatin presence on pharmaceutical properties of designed formulations was assessed. Interrelations among polymers were evaluated with thermal analysis and Fourier transform infrared spectroscopy. A valid aspect of this research was the in vitro antifungal activity estimation of designed microparticles using Candida species: C. albicans, C. krusei, and C. parapsilosis. It was shown that the gelatin addition affected the particles size, improved encapsulation efficiency and mucoadhesiveness, and prolonged the drug release. Moreover, gelatin addition to the formulations improved the antifungal effect against Candida species. |
Afiliacja: | Marta Szekalska - Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland Magdalena Wróblewska - Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland Anna Czajkowska-Kośnik - Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland Katarzyna Sosnowska - Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland Paweł Misiak - Department of Polymers and Organic Synthesis, Faculty of Chemistry, University of Białystok, 15-245 Białystok, Poland Agnieszka Zofia Wilczewska - Department of Polymers and Organic Synthesis, Faculty of Chemistry, University of Białystok, 15-245 Białystok, Poland Katarzyna Winnicka - Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland |
E-mail: | Marta Szekalska: marta.szekalska@umb.edu.pl |
Sponsorzy: | This researchwas funded by Medical University of Bialystok grant SUB/2/DN/22/004/2215. |
URI: | http://hdl.handle.net/11320/16609 |
DOI: | 10.3390/ma16010403 |
ISSN: | 1996-1944 |
metadata.dc.identifier.orcid: | 0000-0003-4340-5350 0000-0002-5782-679X 0000-0002-5025-4864 0000-0001-8528-3764 0000-0002-6882-3519 0000-0001-8587-6711 0000-0002-1013-610X |
Typ Dokumentu: | Article |
metadata.dc.rights.uri: | http://creativecommons.org/licenses/by/4.0/ |
Właściciel praw: | Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
Występuje w kolekcji(ach): | Artykuły naukowe (WChem) |
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Plik | Opis | Rozmiar | Format | |
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M_Szekalska_M_Wroblewska_P_Misiak_at_al_The_Spray_Dried_Alginate_Gelatin_Microparticles.pdf | 5,96 MB | Adobe PDF | Otwórz |
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