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http://hdl.handle.net/11320/18166| Tytuł: | New Steroidal Selenides as Proapoptotic Factors |
| Autorzy: | Jastrzębska, Izabella Wawrusiewicz-Kurylonek, Natalia Grześ, Paweł A. Ratkiewicz, Artur Grabowska, Ewa Czerniecka, Magdalena Czyżewska, Urszula Tylicki, Adam |
| Słowa kluczowe: | antimetabolites cell growth inhibition gene expression HeLa cells |
| Data wydania: | 2023 |
| Data dodania: | 4-kwi-2025 |
| Wydawca: | MDPI |
| Źródło: | Molecules Volume 28, Issue 22 (2023), p. 7528 |
| Abstrakt: | Cytostatic and pro-apoptotic effects of selenium steroid derivatives against HeLa cells were determined. The highest cytostatic activity was shown by derivative 4 (GI₅₀25.0 µM, almost complete growth inhibition after three days of culture, and over 97% of apoptotic and dead cells at 200 µM). The results of our study (cell number measurements, apoptosis profile, relative expression of apoptosis related APAF1, BID, and mevalonate pathway-involved HMGCR, SQLE, CYP51A1, and PDHB genes, and computational chemistry data) support the hypothesis that tested selenosteroids induce the extrinsic pathway of apoptosis by affecting the cell membrane as cholesterol antimetabolites. An additional mechanism of action is possible through a direct action of derivative 4 to inhibit PDHB expression in a way similar to steroid hormones. |
| Afiliacja: | Izabella Jastrzębska - Faculty of Chemistry, University of Białystok Natalia Wawrusiewicz-Kurylonek - Department of Clinical Genetics, Medical University of Białystok Paweł A. Grześ - Faculty of Chemistry, University of Białystok Artur Ratkiewicz - Faculty of Chemistry, University of Białystok Ewa Grabowska - Doctoral School of Exact and Natural Sciences, University of Bialystok Magdalena Czerniecka - Faculty of Biology, University of Białystok Urszula Czyzewska - Faculty of Biology, University of Białystok Adam Tylicki - Faculty of Biology, University of Białystok |
| E-mail: | Izabella Jastrzębska: i.jastrzebska@uwb.edu.pl Adam Tylicki: atyl@uwb.edu.pl |
| Sponsorzy: | This study was supported by the Ministry of Education and Science, Poland, as a part of subsidies for maintaining the research potential granted to the Faculty of Biology (SWB-8) and Faculty of Chemistry of the University of Białystok. The equipment used for the cell culture at the Laboratory of Tissue Culture was funded by the Ministry of Science and Higher Education (grant no. 8636/E342/R/2014; Restructuration of Faculty of Biology and Chemistry). This work was financed from a scientific project by the subsidy of the Medical University of Bialystok (B.SUB.23.306). |
| URI: | http://hdl.handle.net/11320/18166 |
| DOI: | 10.3390/molecules28227528 |
| ISSN: | 1420-3049 |
| metadata.dc.identifier.orcid: | 0000-0003-3268-3515 0000-0002-1087-8154 brakorcid 0000-0003-1657-1871 brakorcid brakorcid brakorcid brakorcid |
| Typ Dokumentu: | Article |
| metadata.dc.rights.uri: | http://creativecommons.org/licenses/by/4.0/ |
| Właściciel praw: | Copyright: © 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| Występuje w kolekcji(ach): | Artykuły naukowe (SzkDokt) Artykuły naukowe (WBiol) Artykuły naukowe (WChem) |
Pliki w tej pozycji:
| Plik | Opis | Rozmiar | Format | |
|---|---|---|---|---|
| I_Jastrzebska_N_Wawrusiewicz_Kurylonek_at_al_New_Steroidal_Selenides.pdf | 9,97 MB | Adobe PDF | Otwórz |
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