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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/18166
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    Pole DCWartośćJęzyk
    dc.contributor.authorJastrzębska, Izabella-
    dc.contributor.authorWawrusiewicz-Kurylonek, Natalia-
    dc.contributor.authorGrześ, Paweł A.-
    dc.contributor.authorRatkiewicz, Artur-
    dc.contributor.authorGrabowska, Ewa-
    dc.contributor.authorCzerniecka, Magdalena-
    dc.contributor.authorCzyżewska, Urszula-
    dc.contributor.authorTylicki, Adam-
    dc.date.accessioned2025-04-04T06:50:29Z-
    dc.date.available2025-04-04T06:50:29Z-
    dc.date.issued2023-
    dc.identifier.citationMolecules Volume 28, Issue 22 (2023), p. 7528pl
    dc.identifier.issn1420-3049-
    dc.identifier.urihttp://hdl.handle.net/11320/18166-
    dc.description.abstractCytostatic and pro-apoptotic effects of selenium steroid derivatives against HeLa cells were determined. The highest cytostatic activity was shown by derivative 4 (GI₅₀25.0 µM, almost complete growth inhibition after three days of culture, and over 97% of apoptotic and dead cells at 200 µM). The results of our study (cell number measurements, apoptosis profile, relative expression of apoptosis related APAF1, BID, and mevalonate pathway-involved HMGCR, SQLE, CYP51A1, and PDHB genes, and computational chemistry data) support the hypothesis that tested selenosteroids induce the extrinsic pathway of apoptosis by affecting the cell membrane as cholesterol antimetabolites. An additional mechanism of action is possible through a direct action of derivative 4 to inhibit PDHB expression in a way similar to steroid hormones.pl
    dc.description.sponsorshipThis study was supported by the Ministry of Education and Science, Poland, as a part of subsidies for maintaining the research potential granted to the Faculty of Biology (SWB-8) and Faculty of Chemistry of the University of Białystok. The equipment used for the cell culture at the Laboratory of Tissue Culture was funded by the Ministry of Science and Higher Education (grant no. 8636/E342/R/2014; Restructuration of Faculty of Biology and Chemistry). This work was financed from a scientific project by the subsidy of the Medical University of Bialystok (B.SUB.23.306).pl
    dc.language.isoenpl
    dc.publisherMDPIpl
    dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
    dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
    dc.subjectantimetabolitespl
    dc.subjectcell growth inhibitionpl
    dc.subjectgene expressionpl
    dc.subjectHeLa cellspl
    dc.titleNew Steroidal Selenides as Proapoptotic Factorspl
    dc.typeArticlepl
    dc.rights.holderCopyright: © 2023 by the authors.pl
    dc.rights.holderThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pl
    dc.identifier.doi10.3390/molecules28227528-
    dc.description.EmailIzabella Jastrzębska: i.jastrzebska@uwb.edu.plpl
    dc.description.EmailAdam Tylicki: atyl@uwb.edu.plpl
    dc.description.AffiliationIzabella Jastrzębska - Faculty of Chemistry, University of Białystokpl
    dc.description.AffiliationNatalia Wawrusiewicz-Kurylonek - Department of Clinical Genetics, Medical University of Białystokpl
    dc.description.AffiliationPaweł A. Grześ - Faculty of Chemistry, University of Białystokpl
    dc.description.AffiliationArtur Ratkiewicz - Faculty of Chemistry, University of Białystokpl
    dc.description.AffiliationEwa Grabowska - Doctoral School of Exact and Natural Sciences, University of Bialystokpl
    dc.description.AffiliationMagdalena Czerniecka - Faculty of Biology, University of Białystokpl
    dc.description.AffiliationUrszula Czyzewska - Faculty of Biology, University of Białystokpl
    dc.description.AffiliationAdam Tylicki - Faculty of Biology, University of Białystokpl
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    dc.description.volume28pl
    dc.description.issue22pl
    dc.description.firstpage7528pl
    dc.identifier.citation2Moleculespl
    dc.identifier.orcid0000-0003-3268-3515-
    dc.identifier.orcid0000-0002-1087-8154-
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    dc.identifier.orcid0000-0003-1657-1871-
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