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http://hdl.handle.net/11320/16602| Tytuł: | Doxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as specific vehicles to fight estrogen-dependent breast cancer |
| Autorzy: | Misiak, Paweł Niemirowicz - Laskowska, Katarzyna Markiewicz, Karolina H. Wielgat, Przemysław Kurowska, Izabela Czarnomysy, Robert Misztalewska - Turkowicz, Iwona Car, Halina Bielawski, Krzysztof Wilczewska, Agnieszka Z. |
| Słowa kluczowe: | Polymeric nanoparticles Cholesterol-end capped poly (Nisopropylacrylamide) Cell-penetrating molecules Breast cancer Doxorubicin Smart drug delivery systems |
| Data wydania: | 2023 |
| Data dodania: | 4-cze-2024 |
| Wydawca: | BMC |
| Źródło: | Cancer Nanotechnology, Volume 14 (2023), p. 1-25 |
| Abstrakt: | The presented research concerns the preparation of polymer nanoparticles (PNPs) for the delivery of doxorubicin. Several block and statistical copolymers, composed of ketoester derivative, N-isopropylacrylamide, and cholesterol, were synthesized. In the nanoprecipitation process, doxorubicin (DOX) molecules were kept in spatial polymeric systems. DOX-loaded PNPs show high efcacy against estrogen-dependent MCF-7 breast cancer cell lines despite low doses of DOX applied and good compatibility with normal cells. Research confrms the efect of PNPs on the degradation of the biological membrane, and the accumulation of reactive oxygen species (ROS), and the ability to cell cycle arrest are strictly linked to cell death. |
| Afiliacja: | Paweł Misiak - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Poland Katarzyna Niemirowicz‑Laskowska - Department of Experimental Pharmacology, Medical University of Bialystok, Mickiewicza 2A, 15‑089 Białystok, Poland Karolina H. Markiewicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Poland Przemysław Wielgat - Department of Clinical Pharmacology, Medical University of Bialystok, Białystok, Poland Izabela Kurowska - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Poland Robert Czarnomysy - Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15‑089 Białystok, Poland Iwona Misztalewska‑Turkowicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Poland Halina Car - Department of Experimental Pharmacology, Medical University of Bialystok, Mickiewicza 2A, 15‑089 Białystok, Poland Krzysztof Bielawski - Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15‑089 Białystok, Poland Agnieszka Z. Wilczewska - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Poland |
| E-mail: | Katarzyna Niemirowicz‑Laskowska: katarzyna.niemirowicz@umb.edu.pl Agnieszka Z. Wilczewska: agawilcz@uwb.edu.pl |
| Sponsorzy: | This work was fnancially supported by the National Science Centre, Poland, grant no. NCN/2016/21/B/ST5/01365. |
| URI: | http://hdl.handle.net/11320/16602 |
| DOI: | 10.1186/s12645-023-00176-9 |
| ISSN: | 1868-6966 |
| Typ Dokumentu: | Article |
| metadata.dc.rights.uri: | http://creativecommons.org/licenses/by/4.0/ |
| Właściciel praw: | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. |
| Występuje w kolekcji(ach): | Artykuły naukowe (WChem) |
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| Plik | Opis | Rozmiar | Format | |
|---|---|---|---|---|
| P_Misiak_K_ Niemirowicz_Laskowska_KH_Markiewicz_P_Wielgat_at_al_Doxorubicin_loaded_polymeric_nanoparticles.pdf | 3,32 MB | Adobe PDF | Otwórz |
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