REPOZYTORIUM UNIWERSYTETU
W BIAŁYMSTOKU
UwB

  1. Repozytorium Uniwersytetu w Białymstoku
  2. Wydział Chemii / Faculty of Chemistry
  3. Artykuły naukowe (WChem)

Szukanie zaawansowane
  • Zespoły i Kolekcje


  • Zaloguj się
  • Zarejestruj się
  • Mój RUB
  • FAQ
  • Polityka
  • Regulamin
  • DOI
  • Instrukcja
  • Aspekty prawne
  • Open Access
  • Archiwum


  • Kontakt
  • O Dspace
  • Strona Biblioteki
  • Strona Uczelni



    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16602
    Pełny rekord metadanych
    Pole DCWartośćJęzyk
    dc.contributor.authorMisiak, Paweł-
    dc.contributor.authorNiemirowicz - Laskowska, Katarzyna-
    dc.contributor.authorMarkiewicz, Karolina H.-
    dc.contributor.authorWielgat, Przemysław-
    dc.contributor.authorKurowska, Izabela-
    dc.contributor.authorCzarnomysy, Robert-
    dc.contributor.authorMisztalewska - Turkowicz, Iwona-
    dc.contributor.authorCar, Halina-
    dc.contributor.authorBielawski, Krzysztof-
    dc.contributor.authorWilczewska, Agnieszka Z.-
    dc.date.accessioned2024-06-04T09:22:17Z-
    dc.date.available2024-06-04T09:22:17Z-
    dc.date.issued2023-
    dc.identifier.citationCancer Nanotechnology, Volume 14 (2023), p. 1-25pl
    dc.identifier.issn1868-6966-
    dc.identifier.urihttp://hdl.handle.net/11320/16602-
    dc.description.abstractThe presented research concerns the preparation of polymer nanoparticles (PNPs) for the delivery of doxorubicin. Several block and statistical copolymers, composed of ketoester derivative, N-isopropylacrylamide, and cholesterol, were synthesized. In the nanoprecipitation process, doxorubicin (DOX) molecules were kept in spatial polymeric systems. DOX-loaded PNPs show high efcacy against estrogen-dependent MCF-7 breast cancer cell lines despite low doses of DOX applied and good compatibility with normal cells. Research confrms the efect of PNPs on the degradation of the biological membrane, and the accumulation of reactive oxygen species (ROS), and the ability to cell cycle arrest are strictly linked to cell death.pl
    dc.description.sponsorshipThis work was fnancially supported by the National Science Centre, Poland, grant no. NCN/2016/21/B/ST5/01365.pl
    dc.language.isoenpl
    dc.publisherBMCpl
    dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
    dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
    dc.subjectPolymeric nanoparticlespl
    dc.subjectCholesterol-end capped poly (Nisopropylacrylamide)pl
    dc.subjectCell-penetrating moleculespl
    dc.subjectBreast cancerpl
    dc.subjectDoxorubicinpl
    dc.subjectSmart drug delivery systemspl
    dc.titleDoxorubicin-loaded polymeric nanoparticles containing ketoester-based block and cholesterol moiety as specific vehicles to fight estrogen-dependent breast cancerpl
    dc.typeArticlepl
    dc.rights.holder© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.pl
    dc.identifier.doi10.1186/s12645-023-00176-9-
    dc.description.EmailKatarzyna Niemirowicz‑Laskowska: katarzyna.niemirowicz@umb.edu.plpl
    dc.description.EmailAgnieszka Z. Wilczewska: agawilcz@uwb.edu.plpl
    dc.description.AffiliationPaweł Misiak - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Polandpl
    dc.description.AffiliationKatarzyna Niemirowicz‑Laskowska - Department of Experimental Pharmacology, Medical University of Bialystok, Mickiewicza 2A, 15‑089 Białystok, Polandpl
    dc.description.AffiliationKarolina H. Markiewicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Polandpl
    dc.description.AffiliationPrzemysław Wielgat - Department of Clinical Pharmacology, Medical University of Bialystok, Białystok, Polandpl
    dc.description.AffiliationIzabela Kurowska - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Polandpl
    dc.description.AffiliationRobert Czarnomysy - Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15‑089 Białystok, Polandpl
    dc.description.AffiliationIwona Misztalewska‑Turkowicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Polandpl
    dc.description.AffiliationHalina Car - Department of Experimental Pharmacology, Medical University of Bialystok, Mickiewicza 2A, 15‑089 Białystok, Polandpl
    dc.description.AffiliationKrzysztof Bielawski - Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15‑089 Białystok, Polandpl
    dc.description.AffiliationAgnieszka Z. Wilczewska - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Białystok, Polandpl
    dc.description.referencesAmin K, Dannenfelser R-M (2006) In vitro hemolysis: guidance for the pharmaceutical scientist. J Pharm Sci 95(6):1173–1176.pl
    dc.description.referencesAnsari L, Shiehzadeh F, Taherzadeh Z, Nikoofal-Sahlabadi S, Momtazi-borojeni AA, Sahebkar A et al (2017) The most prevalent side efects of pegylated liposomal doxorubicin monotherapy in women with metastatic breast cancer: a systematic review of clinical trials. Cancer Gene Ther 24(5):189–193.pl
    dc.description.referencesAvramović N, Mandić B, Savić-Radojević A, Simić T (2020) Polymeric nanocarriers of drug delivery systems in cancer therapy. Pharmaceutics 12(4):298.pl
    dc.description.referencesBray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424.pl
    dc.description.referencesBrenneisen P, Reichert AS (2018) Nanotherapy and reactive oxygen species (ROS) in cancer: a novel perspective. Antioxi‑dants 7(2):31.pl
    dc.description.referencesCammas S, Suzuki K, Sone C, Sakurai Y, Kataoka K, Okano T (1997) Thermo-responsive polymer nanoparticles with a coreshell micelle structure as site-specifc drug carriers. J Control Release 48(2–3):157–164.pl
    dc.description.referencesCarvalho C, Santos XR, Cardoso S, Correia S, Oliveira JP, Santos SM et al (2009) Doxorubicin: the good, the bad and the ugly efect. Curr Med Chem 16(25):3267–3285.pl
    dc.description.referencesCerqueira NMFSA, Oliveira EF, Gesto DS, Santos-Martins D, Moreira C, Moorthy HN et al (2016) Cholesterol biosynthesis: a mechanistic overview. Biochemistry 55(39):5483–5506.pl
    dc.description.referencesChen H-H, Lu I-L, Liu T-I, Tsai Y-C, Chiang W-H, Lin S-C et al (2019) Indocyanine green/doxorubicin-encapsulated functionalized nanoparticles for efective combination therapy against human MDR breast cancer. Colloids Surf B Biointerfaces 177:294–305.pl
    dc.description.referencesCho H, Cho Y-Y, Shim MS, Lee JY, Lee HS, Kang HC (2020) Mitochondria-targeted drug delivery in cancers. Biochim Biophys Acta BBA Mol Basis Dis. 1866(8):165808.pl
    dc.description.referencesd’Avanzo N, Torrieri G, Figueiredo P, Celia C, Paolino D, Correia A et al (2021) LinTT1 peptide-functionalized liposomes for targeted breast cancer therapy. Int J Pharm 597:120346.pl
    dc.description.referencesde la Harpe KM, Kondiah PPD, Choonara YE, Marimuthu T, du Toit LC, Pillay V (2019) The hemocompatibility of nanoparticles: a review of cell-nanoparticle interactions and hemostasis. Cells 8(10):1209.pl
    dc.description.referencesDi J, Gao X, Du Y, Zhang H, Gao J, Zheng A (2021) Size, shape, charge and “stealthy” surface: carrier properties afect the drug circulation time in vivo. Asian J Pharm Sci 16(4):444–458.pl
    dc.description.referencesDon T-M, Lu K-Y, Lin L-J, Hsu C-H, Wu J-Y, Mi F-L (2017) Temperature/pH/enzyme triple-responsive cationic protein/PAAb-PNIPAAm nanogels for controlled anticancer drug and photosensitizer delivery against multidrug resistant breast cancer cells. Mol Pharm 14(12):4648–4660.pl
    dc.description.referencesDu M, Ouyang Y, Meng F, Ma Q, Liu H, Zhuang Y et al (2019) Nanotargeted agents: an emerging therapeutic strategy for breast cancer. Nanomed Future Med 14(13):1771–1786.pl
    dc.description.referencesFrederick CA, Williams LD, Ughetto G, Van der Marel GA, Van Boom JH, Rich A et al (1990) Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin. Biochemistry 29(10):2538–2549.pl
    dc.description.referencesGonçalves M, Mignani S, Rodrigues J, Tomás H (2020) A glance over doxorubicin based-nanotherapeutics: from proof-ofconcept studies to solutions in the market. J Control Release 317:347–374.pl
    dc.description.referencesGratton SEA, Ropp PA, Pohlhaus PD, Luft JC, Madden VJ, Napier ME et al (2008) The efect of particle design on cellular internalization pathways. Proc Natl Acad Sci 105(33):11613–11618.pl
    dc.description.referencesGreen AE, Rose PG (2006) Pegylated liposomal doxorubicin in ovarian cancer. Int J Nanomedicine 1(3):229–239.pl
    dc.description.referencesGurunathan S, Kang M-H, Qasim M, Kim J-H (2018) Nanoparticle-mediated combination therapy: two-in-one approach for cancer. Int J Mol Sci 19(10):3264.pl
    dc.description.referencesHan S-S, Li Z-Y, Zhu J-Y, Han K, Zeng Z-Y, Hong W et al (2015) Dual-pH sensitive charge-reversal polypeptide micelles for tumor-triggered targeting uptake and nuclear drug delivery. Small 11(21):2543–2554.pl
    dc.description.referencesHe W, Ma Y, Gao X, Wang X, Dai X, Song J (2020) Application of poly(N-isopropylacrylamide) as thermosensitive smart materials. J Phys Conf Ser 1676:012063.pl
    dc.description.referencesHortobágyi GN (1997) Anthrazykline in der Krebstherapie: Ein Überblick. Drugs 54(Supplement 4):1–7.pl
    dc.description.referencesIbiyeye KM, Nordin N, Ajat M, Zuki ABZ (2019) Ultrastructural changes and antitumor efects of doxorubicin/thymoquinone-loaded CaCO3 nanoparticles on breast cancer cell line. Front Oncol. https://doi.org/10.3389/fonc.2019.00599.pl
    dc.description.referencesJasinski DL, Li H, Guo P (2018) The efect of size and shape of RNA nanoparticles on biodistribution. Mol Ther 26(3):784–792pl
    dc.description.referencesKim S, Oh W-K, Jeong YS, Hong J-Y, Cho B-R, Hahn J-S et al (2011) Cytotoxicity of, and innate immune response to, sizecontrolled polypyrrole nanoparticles in mammalian cells. Biomaterials 32(9):2342–2350.pl
    dc.description.referencesKurowska I, Amouroux B, Langlais M, Coutelier O, Coudret C, Destarac M et al (2022a) Versatile thiolactone-based conjugation strategies to polymer stabilizers for multifunctional upconverting nanoparticles aqueous dispersions. Nanoscale. https://doi.org/10.1039/d1nr05548hpl
    dc.description.referencesKurowska I, Markiewicz KH, Niemirowicz-Laskowska K, Misiak P, Destarac M, Wielgat P et al (2022b) Membrane-active-diacylglycerol-terminated thermoresponsive polymers: RAFT synthesis and biocompatibility evaluation. Eur Polym J 169:111154.pl
    dc.description.referencesLeekha A, Kumar V, Moin I, Gurjar BS, Verma AK (2019) Modulation of oxidative stress by doxorubicin loaded chitosan nanoparticles. J Cancer Res Pract 6(2):76.pl
    dc.description.referencesLeonard RCF, Williams S, Tulpule A, Levine AM, Oliveros S (2009) Improving the therapeutic index of anthracycline chemotherapy: Focus on liposomal doxorubicin (Myocet™). Breast 18(4):218–224.pl
    dc.description.referencesLi Q, Huang C, Liu L, Hu R, Qu J (2018) Efect of surface coating of gold nanoparticles on cytotoxicity and cell cycle progression. Nanomaterials 8(12):1063.pl
    dc.description.referencesLi Y, Yang J, Sun X (2021) Reactive oxygen species-based nanomaterials for cancer therapy. Front Chem. https://doi.org/10.3389/fchem.2021.650587.pl
    dc.description.referencesLópez-García J, Lehocký M, Humpolíček P, Sáha P (2014) HaCaT keratinocytes response on antimicrobial atelocollagen substrates: extent of cytotoxicity, cell viability and proliferation. J Funct Biomater 5(2):43–57.pl
    dc.description.referencesLudwig H, Van Belle S, Barrett-Lee P, Birgegård G, Bokemeyer C, Gascón P et al (2004) The European Cancer Anaemia Survey (ECAS): a large, multinational, prospective survey defning the prevalence, incidence, and treatment of anaemia in cancer patients. Eur J Cancer 40(15):2293–2306.pl
    dc.description.referencesLv S, Li M, Tang Z, Song W, Sun H, Liu H et al (2013) Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efcient drug delivery system for cancer therapy. Acta Biomater 9(12):9330–9342.pl
    dc.description.referencesMahmoudi M, Azadmanesh K, Shokrgozar MA, Journeay WS, Laurent S (2011) Efect of nanoparticles on the cell life cycle. Chem Rev 111(5):3407–3432.pl
    dc.description.referencesMarkiewicz KH, Niemirowicz-Laskowska K, Szymczuk D, Makarewicz K, Misztalewska-Turkowicz I, Wielgat P et al (2021) Magnetic particles with polymeric shells bearing cholesterol moieties sensitize breast cancer cells to low doses of doxorubicin. Int J Mol Sci 22(9):4898.pl
    dc.description.referencesMarouf NF, Vahedian V, Mazrakhondi SAM, Kooti W, Khiavy HA, Bazzaz R et al (2020) Sensitization of MDA-MBA231 breast cancer cell to docetaxel by myricetin loaded into biocompatible lipid nanoparticles via sub-G1 cell cycle arrest mechanism. Naunyn Schmiedebergs Arch Pharmacol 393(1):1–11.pl
    dc.description.referencesMetawea ORM, Abdelmoneem MA, Haiba NS, Khalil HH, Teleb M, Elzoghby AO et al (2021) A novel ‘smart’ PNIPAM-based copolymer for breast cancer targeted therapy: synthesis, and characterization of dual pH/temperature-responsive lactoferrin-targeted PNIPAM-co-AA. Colloids Surf B Biointerfaces 202:111694. https://doi.org/10.1016/j.colsurfb.2021.111694.pl
    dc.description.referencesMisiak P, Markiewicz KH, Szymczuk D, Wilczewska AZ (2020a) Polymeric drug delivery systems bearing cholesterol moieties: a review. Polymers 12(11):2620.pl
    dc.description.referencesMisiak P, Niemirowicz-Laskowska K, Markiewicz KH, Misztalewska-Turkowicz I, Wielgat P, Kurowska I et al (2020b) Evaluation of cytotoxic efect of cholesterol end-capped poly(N-isopropylacrylamide)s on selected normal and neoplastic cells. Int J Nanomedicine 15:7263–7278.pl
    dc.description.referencesMisiak P, Niemirowicz-Laskowska K, Misztalewska-Turkowicz I, Markiewicz KH, Wielgat P, Car H et al (2022) Doxorubicin delivery systems with an acetylacetone-based block in cholesterol-terminated copolymers: diverse activity against estrogen-dependent and estrogen-independent breast cancer cells. Chem Phys Lipids 245:105194. https://doi.org/10.1016/j.chemphyslip.2022.105194.pl
    dc.description.referencesMussi SV, Sawant R, Perche F, Oliveira MC, Azevedo RB, Ferreira LAM et al (2014) Novel nanostructured lipid carrier coloaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. Pharm Res 31(8):1882–1892.pl
    dc.description.referencesNes WD (2011) Biosynthesis of cholesterol and other sterols. Chem Rev 111(10):6423–6451.pl
    dc.description.referencesNiaz S, Forbes B, Raimi-Abraham BT (2022) Exploiting endocytosis for non-spherical nanoparticle cellular uptake. Nanomanufacturing 2(1):1–16.pl
    dc.description.referencesNowak M, Brown TD, Graham A, Helgeson ME, Mitragotri S (2020) Size, shape, and fexibility infuence nanoparticle transport across brain endothelium under fow. Bioeng Transl Med. https://doi.org/10.1002/btm2.10153.pl
    dc.description.referencesOlim F, Neves AR, Vieira M, Tomás H, Sheng R (2021) Self-assembly of cholesterol-doxorubicin and TPGS into prodrugbased nanoparticles with enhanced cellular uptake and lysosome-dependent pathway in breast cancer cells. Eur J Lipid Sci Technol 123(5):2000337.pl
    dc.description.referencesPaul Launchbury A, Habboubi N (1993) Epirubicin and doxorubicin: a comparison of their characteristics, therapeutic activity and toxicity. Cancer Treat Rev 19(3):197–228.pl
    dc.description.referencesPigram WJ, Fuller W, Hamilton LD (1972) Stereochemistry of intercalation: interaction of daunomycin with DNA. Nat New Biol 235(53):17–19.pl
    dc.description.referencesPommier Y, Leo E, Zhang H, Marchand C (2010) DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol 17(5):421–433.pl
    dc.description.referencesRafyath SM, Rasul M, Lee B, Wei G, Lamba G, Liu D (2012) Comparison of safety and toxicity of liposomal doxorubicin vs.conventional anthracyclines: a meta-analysis. Exp Hematol Oncol 1(1):10.pl
    dc.description.referencesRawat PS, Jaiswal A, Khurana A, Bhatti JS, Navik U (2021) Doxorubicin-induced cardiotoxicity: an update on the molecular mechanism and novel therapeutic strategies for efective management. Biomed Pharmacother 139:111708.pl
    dc.description.referencesRivankar S (2014) An overview of doxorubicin formulations in cancer therapy. J Cancer Res Ther 10(4):853.pl
    dc.description.referencesRoser M, Fischer D, Kissel T (1998) Surface-modifed biodegradable albumin nano- and microspheres. II: efect of surface charges on in vitro phagocytosis and biodistribution in rats. Eur J Pharm Biopharm 46(3):255–263.pl
    dc.description.referencesSadava DE (ed) (2011) Life: the science of biology, 9th edn. Sinauer Associates, W. H. Freeman & Co, Sunderland.pl
    dc.description.referencesSafra T (2003) Cardiac safety of liposomal anthracyclines. Oncologist 8(S2):17–24.pl
    dc.description.referencesSenapati S, Mahanta AK, Kumar S, Maiti P (2018) Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduct Target Ther 3(1):1–19.pl
    dc.description.referencesShan K, Lincof AM, Young JB (1996) Anthracycline-induced cardiotoxicity. Ann Intern Med 125(1):47–58.pl
    dc.description.referencesShin HH, Choi HW, Lim JH, Kim JW, Chung BG (2020) Near-infrared light-triggered thermo-responsive poly(Nisopropylacrylamide)-pyrrole nanocomposites for chemo-photothermal cancer therapy. Nanoscale Res Lett 15(1):214. https://doi.org/10.1186/s11671-020-03444-4.pl
    dc.description.referencesSullivan LB, Chandel NS (2014) Mitochondrial reactive oxygen species and cancer. Cancer Metab 2(1):17.pl
    dc.description.referencesSung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249.pl
    dc.description.referencesSznarkowska A, Kostecka A, Meller K, Bielawski KP (2016) Inhibition of cancer antioxidant defense by natural compounds. Oncotarget 8(9):15996–16016.pl
    dc.description.referencesTacar O, Sriamornsak P, Dass CR (2012) Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol 65(2):157–170.pl
    dc.description.referencesTahover E, Patil YP, Gabizon AA (2015) Emerging delivery systems to reduce doxorubicin cardiotoxicity and improve therapeutic index: focus on liposomes. Anticancer Drugs 26(3):241–258.pl
    dc.description.referencesThigpen JT (2005) Innovations in anthracycline therapy: overview. Commun Oncol 2:3–7.pl
    dc.description.referencesTorchilin VP (2012) Multifunctional nanocarriers. Adv Drug Deliv Rev 64:302–315.pl
    dc.description.referencesTotea G, Ionita D, Demetrescu I, Mitache M (2014) In vitro hemocompatibility and corrosion behavior of new Zr-binary alloys in whole human blood. Open Chem 12(796–803):796.pl
    dc.description.referencesVolkova M, Russell R (2012) Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment. Curr Cardiol Rev 7(4):214–220.pl
    dc.description.referencesWang H-Y, Hua X-W, Jia H-R, Liu P, Gu N, Chen Z et al (2016) Enhanced cell membrane enrichment and subsequent cellular internalization of quantum dots via cell surface engineering: illuminating plasma membranes with quantum dots. J Mater Chem B 4(5):834–843.pl
    dc.description.referencesWang YM, Zheng SX, Chang HI, Tsai HY, Liang M (2017) Microwave-assisted synthesis of thermo- and pH-responsive antitumor drug carrier through reversible addition–fragmentation chain transfer polymerization. Express Polym Lett 11(4):293–307.pl
    dc.description.referencesWang H, Li Z, Lu S, Li C, Zhao W, Zhao Y et al (2020) Nano micelles of cellulose-graft-poly (l-lactic acid) anchored with epithelial cell adhesion antibody for enhanced drug loading and anti-tumor efect. Mater Today Commun 22:100764.pl
    dc.description.referencesWicki A, Witzigmann D, Balasubramanian V, Huwyler J (2015) Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications. J Controlled Release 200:138–157.pl
    dc.description.referencesXu Z, Yang D, Long T, Yuan L, Qiu S, Li D et al (2022) pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modifed hydroxyethyl starch for tumor chemotherapy. Carbohydr Polym 277:118827.pl
    dc.description.referencesYang F, Teves SS, Kemp CJ, Henikof S (2014) Doxorubicin, DNA torsion, and chromatin dynamics. Biochim Biophys Acta BBA Rev Cancer 1845(1):84–89.pl
    dc.description.referencesYang C, Liu SQ, Venkataraman S, Gao SJ, Ke X, Chia XT et al (2015) Structure-directing star-shaped block copolymers: Supramolecular vesicles for the delivery of anticancer drugs. J Controlled Release 208:93–105.pl
    dc.description.referencesYe P, Ye Y, Chen X, Zou H, Zhou Y, Zhao X et al (2020) Ultrasmall Fe3O4 nanoparticles induce S-phase arrest and inhibit cancer cells proliferation. Nanotechnol Rev 9(1):61–69.pl
    dc.description.referencesZhang Y, Xiao C, Li M, Ding J, Yang C, Zhuang X et al (2014) Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efcacy. Sci China Chem 57(4):624–632.pl
    dc.description.referencesZhang CY, Chen Q, Wu WS, Guo XD, Cai CZ, Zhang LJ (2016) Synthesis and evaluation of cholesterol-grafted PEGylated peptides with pH-triggered property as novel drug carriers for cancer chemotherapy. Colloids Surf B Biointerfaces 142:55–64.pl
    dc.description.referencesZhang R, Qin X, Kong F, Chen P, Pan G (2019) Improving cellular uptake of therapeutic entities through interaction with components of cell membrane. Drug Deliv 26(1):328–342.pl
    dc.description.volume14pl
    dc.description.firstpage1pl
    dc.description.lastpage25pl
    dc.identifier.citation2Cancer Nanotechnologypl
    Występuje w kolekcji(ach):Artykuły naukowe (WChem)

    Pliki w tej pozycji:
    Plik Opis RozmiarFormat 
    P_Misiak_K_ Niemirowicz_Laskowska_KH_Markiewicz_P_Wielgat_at_al_Doxorubicin_loaded_polymeric_nanoparticles.pdf3,32 MBAdobe PDFOtwórz
    Pokaż uproszczony widok rekordu Zobacz statystyki


    Pozycja ta dostępna jest na podstawie licencji Licencja Creative Commons CCL Creative Commons