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http://hdl.handle.net/11320/16598
Tytuł: | Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles |
Autorzy: | Niemirowicz-Laskowska, Katarzyna Mystkowska, Joanna Łysik, Dawid Chmielewska, Sylwia Tokajuk, Grażyna Misztalewska-Turkowicz, Iwona Wilczewska, Agnieszka Z. Bucki, Robert |
Słowa kluczowe: | saliva magnetic nanoparticles antimicrobial biofilm nanomedicine |
Data wydania: | 2020 |
Data dodania: | 3-cze-2024 |
Wydawca: | MDPI |
Źródło: | International Journal of Molecular Sciences, Vol. 21, Issue 6 (2020), p. 1-17 |
Abstrakt: | Saliva plays a crucial role in oral cavity. In addition to its buffering and moisturizing properties, saliva fulfills many biofunctional requirements, including antibacterial activity that is essential to assure proper oral microbiota growth. Due to numerous extra- and intra-systemic factors, there are many disorders of its secretion, leading to oral dryness. Saliva substitutes used in such situations must meet many demands. This study was design to evaluate the effect of core-shell magnetic nanoparticles (MNPs) adding (gold-coated and aminosilane-coated nanoparticles NPs) on antimicrobial (microorganism adhesion, biofilm formation), rheological (viscosity, viscoelasticity) and physicochemical (pH, surface tension, conductivity) properties of three commercially available saliva formulations. Upon the addition of NPs (20 µg/mL), antibacterial activity of artificial saliva was found to increase against tested microorganisms by 20% to 50%. NPs, especially gold-coated ones, decrease the adhesion of Gram-positive and fungal cells by 65% and Gram-negative bacteria cells by 45%. Moreover, the addition of NPs strengthened the antimicrobial properties of tested artificial saliva, without influencing their rheological and physicochemical properties, which stay within the range characterizing the natural saliva collected from healthy subjects. |
Afiliacja: | Katarzyna Niemirowicz-Laskowska - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok Joanna Mystkowska - Institute of Biomedical Engineering, Bialystok University of Technology Dawid Łysik - Institute of Biomedical Engineering, Bialystok University of Technology Sylwia Chmielewska - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok Grażyna Tokajuk - Department of Integrated Dentistry, Medical University of Bialystok Iwona Misztalewska-Turkowicz - Faculty of Chemistry, University of Białystok Agnieszka Z. Wilczewska - Faculty of Chemistry, University of Białystok Robert Bucki - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok; Department of Microbiology and Immunology, The Faculty of Medicine and Health Sciences of the Jan Kochanowski University in Kielce |
E-mail: | Katarzyna Niemirowicz-Laskowska: katia146@wp.pl Joanna Mystkowska: j.mystkowska@pb.edu.pl Dawid Łysik: d.lysik@pb.edu.pl Sylwia Chmielewska: sylwia.chmielewska@umb.edu.pl Grażyna Tokajuk: grazyna.t1@gmail.com Iwona Misztalewska-Turkowicz: i.misztalewska@uwb.edu.pl Agnieszka Z. Wilczewska: agawilczuwb@gmail.com Robert Bucki: buckirobert@gmail.com |
Sponsorzy: | The study was sponsored by a grant from the Polpharma Scientific Foundation (Katarzyna Niemirowicz-Laskowska). |
URI: | http://hdl.handle.net/11320/16598 |
DOI: | 10.3390/ijms21061979 |
ISSN: | 1422-0067 |
metadata.dc.identifier.orcid: | 0000-0002-3311-7147 0000-0002-3386-146X 0000-0002-5370-0030 brakorcid brakorcid brakorcid brakorcid 0000-0001-7664-9226 |
Typ Dokumentu: | Article |
metadata.dc.rights.uri: | http://creativecommons.org/licenses/by/4.0/ |
Właściciel praw: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Występuje w kolekcji(ach): | Artykuły naukowe (WChem) |
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