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Tytuł: Microextraction of tigecycline using deep eutectic solvents and its determination in milk by LC-MS/MS method
Autorzy: Kiszkiel-Taudul, Ilona
Stankiewicz, Patrycja
Słowa kluczowe: tigecycline
antibacterial agents
hydrophobic deep eutectic solvents
liquid−liquid microextraction
liquid chromatography
tandem mass spectrometry
dairy products
Data wydania: 2023
Data dodania: 20-wrz-2023
Wydawca: ACS Publications
Źródło: Journal of Agricultural and Food Chemistry, 2023, 71, 11716-11725
Abstrakt: The occurrence of tigecycline (TGC), a new first glycylcycline antibiotic residues in food products harmfully influences potential human consumers health. Therefore, analysts are forced to develop new microextraction methods connected with modern extractants for effective isolation of this compound. For this purpose, deep eutectic solvents (DES) as the extraction media were used. Liquid−liquid microextraction (LLME) of tigecycline from milk samples with application of the hydrophobic deep eutectic solvents: decanoic acid:thymol (1:1), thymol:camphor (2:1), dodecanoic acid:menthol (2:1), and dodecanoic acid:dodecanol (1:1) was developed. The studied samples were subjected to a deproteinization process using trichloroacetic acid solution and acetonitrile. The optimal microextraction parameters, molar ratio of DES components, amount of extraction solvents, pH of milk sample, shaking, and centrifugation time, were chosen. Tigecycline in the obtained microextracts of deep eutectic solvents was analyzed using a liquid chromatographic technique connected with a tandem mass spectrometry (LC-MS/MS) system. The limits of detection and quantification values for TGC determination followed by DES-LLME-LC-MS/MS method were in the 1.8 × 10−11 mol L−1 (0.01 μg kg−1) to 4.0 × 10−9 mol L−1 (2.28 μg kg−1) and 5.5 × 10−11 mol L−1 (0.03 μg kg−1) to 1.2 × 10−8 mol L−1 (6.84 μg kg−1) ranges, respectively. The RSD values of precision were in the range 1.4−7.8% (intraday) and 5.4−11.7% (interday). The developed procedures were used for the determination of tigecycline in different bovine milk samples.
Afiliacja: Ilona Kiszkiel-Taudul − Chemical Department, University of Bialystok
Patrycja Stankiewicz − Chemical Department, University of Bialystok
E-mail: Ilona Kiszkiel-Taudul:
Sponsorzy: This research was funded in part by National Science Centre, Poland, no. 2021/05/X/ST4/00517 (Miniature 5).
This article has received financial support from the Polish Ministry of Education and Science under subsidy for maintaining the research potential of the Faculty of Chemistry, University of Bialystok.
The measurements were carried out on apparatus purchased by EU founds funds via project BioNanoTechno no. POPW.013.00-20-00411.
Opis: Research data: Repozytorium Otwartych Danych RepOD (DOI:
DOI: 10.1021/acs.jafc.3c03023
ISSN: 0021-8561
e-ISSN: 1520-5118
metadata.dc.identifier.orcid: 0000-0001-7168-0531
Typ Dokumentu: Article
Występuje w kolekcji(ach):Artykuły naukowe (WChem)

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