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http://hdl.handle.net/11320/14988
Tytuł: | Caffeic Acid/Eu(III) Complexes: Solution Equilibrium Studies, Structure Characterization and Biological Activity |
Autorzy: | Arciszewska, Żaneta Gama, Sofia Kalinowska, Monika Świderski, Grzegorz Świsłocka, Renata Gołębiewska, Ewelina Naumowicz, Monika Worobiczuk, Mateusz Cudowski, Adam Pietryczuk, Anna De Stefano, Concetta Milea, Demetrio Lewandowski, Włodzimierz Godlewska-Żyłkiewicz, Beata |
Słowa kluczowe: | antimicrobial activity antioxidant activity chemical speciation lanthanides metal complexes microelectrophoretic mobility polyphenols sequestering ability solution equilibria |
Data wydania: | 2022 |
Data dodania: | 19-maj-2023 |
Wydawca: | MDPI |
Źródło: | International Journal of Molecular Sciences, Volume 23 Issue 2 (2022), pp.1-29 |
Abstrakt: | Caffeic acid (CFA) is one of the various natural antioxidants and chemoprotective agents occurring in the human diet. In addition, its metal complexes play fundamental roles in biological systems. Nevertheless, research on the properties of CFA with lanthanide metals is very scarce, and little to no chemical or biological information is known about these particular systems. Most of their properties, including their biological activity and environmental impact, strictly depend on their structure, stability, and solution behaviour. In this work, a multi-analytical-technique approach was used to study these relationships for the Eu(III)/CFA complex. The synthesized metal complex was studied by FT-IR, FT-Raman, elemental, and thermal (TGA) analysis. In order to examine the chemical speciation of the Eu(III)/CFA system in an aqueous solution, several independent potentiometric and spectrophotometric UV-Vis titrations were performed at different M:L (metal:ligand) and pH ratios. The general molecular formula of the synthesized metal complex in the solid state was [Eu(CFA)3(H2O)3]·2H2O (M:L ratio 1:3), while in aqueous solution the 1:1 species were observed at the optimum pH of 6 ≤ pH ≤ 10, ([Eu(CFA)] and [Eu(CFA)(OH)]−). These results were confirmed by 1H-NMR experiments and electrospray-ionization mass spectrometry (ESI-MS). To evaluate the interaction of Eu(III)/CFA and CFA alone with cell membranes, electrophoretic mobility assays were used. Various antioxidant tests have shown that Eu(III)/CFA exhibits lower antioxidant activity than the free CFA ligand. In addition, the antimicrobial properties of Eu(III)/CFA and CFA against Escherichia coli, Bacillus subtilis and Candida albicans were investigated by evaluation of the minimum inhibitory concentration (MIC). Eu(III)/CFA shows higher antibacterial activity against bacteria compared to CFA, which can be explained by the highly probable increased lipophilicity of the Eu(III) complex. |
Afiliacja: | Żaneta Arciszewska - Department of Analytical and Inorganic Chemistry, Faculty of Chemistry, University of Bialystok Sofia Gama - Department of Analytical and Inorganic Chemistry, Faculty of Chemistry, University of Bialystok Monika Kalinowska - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology Grzegorz Świderski - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology Renata Świsłocka - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology Ewelina Gołębiewska - Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology Monika Naumowicz - Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok Mateusz Worobiczuk - Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok Adam Cudowski - Department of Water Ecology, Faculty of Biology, University of Bialystok Anna Pietryczuk - Department of Water Ecology, Faculty of Biology, University of Bialystok Concetta De Stefano - Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, CHIBIOFARAM, Università degli Studi di Messina Demetrio Milea - Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, CHIBIOFARAM, Università degli Studi di Messina Włodzimierz Lewandowski - Prof Waclaw Dabrowski Institute of Agricultural and Food Biotechnology—State Research Institute Beata Godlewska-Żyłkiewicz - Department of Analytical and Inorganic Chemistry, Faculty of Chemistry, University of Bialystok |
E-mail: | Żaneta Arciszewska: z.arciszewska@uwb.edu.pl Sofia Gama: a.gama@uwb.edu.pl Monika Kalinowska: m.kalinowska@pb.edu.pl Grzegorz Świderski: g.swiderski@pb.edu.pl Renata Świsłocka: r.swislocka@pb.edu.pl Ewelina Gołębiewska: e.golebiewska@pb.edu.pl Monika Naumowicz: monikan@uwb.edu.pl Mateusz Worobiczuk: mworobiczuk@gmail.com Adam Cudowski: cudad@uwb.edu.pl Anna Pietryczuk: annapiet@uwb.edu.pl Concetta De Stefano: cdestefano@unime.it Demetrio Milea: dmilea@unime.it Włodzimierz Lewandowski: ; w.lewandowski@pb.edu.pl Beata Godlewska-Żyłkiewicz: bgodlew@uwb.edu.pl |
Sponsorzy: | This research was funded by the National Science Centre (NCN), Poland, under the research project number 2018/29/B/NZ9/01997. This publication is also based upon work from COST Action CA18202—NECTAR—Network for Equilibria and Chemical Thermodynamics Advanced Research, supported by COST (European Cooperation in Science and Technology). |
URI: | http://hdl.handle.net/11320/14988 |
DOI: | 10.3390/ijms23020888 |
ISSN: | 1661-6596 |
e-ISSN: | 1422-0067 |
metadata.dc.identifier.orcid: | 0000-0001-9307-8146 0000-0002-9689-7435 0000-0002-0839-9891 0000-0003-4442-6348 0000-0001-7034-9126 0000-0002-5039-9537 0000-0001-5229-1805 0000-0002-4886-0232 0000-0001-8783-454X 0000-0002-8820-5216 0000-0002-2520-2827 0000-0003-1188-8837 brakorcid 0000-0002-2576-4029 |
Typ Dokumentu: | Article |
metadata.dc.rights.uri: | http://creativecommons.org/licenses/by/4.0/ |
Właściciel praw: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license |
Występuje w kolekcji(ach): | Artykuły naukowe (WChem) |
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