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    Pole DCWartośćJęzyk
    dc.contributor.authorSzymczuk, Dawid-
    dc.contributor.authorMarkiewicz, Karolina H.-
    dc.contributor.authorNiemirowicz-Laskowska, Katarzyna-
    dc.contributor.authorSawicka, Diana-
    dc.contributor.authorMisztalewska-Turkowicz, Iwona-
    dc.contributor.authorCar, Halina-
    dc.contributor.authorWilczewska, Agnieszka Z.-
    dc.date.accessioned2025-11-25T10:10:59Z-
    dc.date.available2025-11-25T10:10:59Z-
    dc.date.issued2025-
    dc.identifier.citationRSC Advances, vol. 15, no. 18, 2025, pp. 14246–14258pl
    dc.identifier.urihttp://hdl.handle.net/11320/19309-
    dc.descriptionThe authors are grateful to Dr Przemysław Wielgat for help with the cell culture.pl
    dc.description.abstractThis study explores the effectiveness against selected cancer cell lines of nano-engineered formulations composed of inorganic cores with steroid-based polymeric shells functionalized with either a targeting or chemotherapeutic agent. We present the synthesis and comprehensive characterization of iron oxide nanoparticles coated by polymeric layers derived from lithocholic acid with covalently affixed folic acid or doxorubicin entities. The cytotoxicity assessments against normal (RBCs, THP-1, CCD-1079sk, and H9C2(2-1) and cancerous (MCF-7, MDA-MB-231, and HeLa) cell lines were performed using two independent endpoint (MTT and neural red) assays. In the case of cancer cells, transepithelial electrical resistance (TERR) and caspase 8 and 9 expression were examined. Additionally, the impact on the activity of xenobiotic metabolizing enzymes from the cytochrome family has been assessed. The results of the study confirmed the selectivity of the synthesized hybrids against tested cancer cells and their ability to induce apoptosis via caspase activation.pl
    dc.description.sponsorshipThis work was financially supported by the National Science Center, Poland, grant no. NCN/ 2019/35/B/ST5/03391 (A. Z. W.) and by the Medical University of Bialystok, Poland B.SUB.23.215 (HC) and B.SUB.23.257 (K. N.-L). The analyses were performed in the Center of Synthesis and Analysis BioNanoTechno of the University of Bialystok. The equipment in the Center was funded by the EU as part of the Operational Program Development of Eastern Poland 2007–2013, projects POPW.01.03.00-20-034/09-00 and POPW.01.03.00-20-004/11.pl
    dc.language.isoenpl
    dc.publisherThe Royal Society of Chemistrypl
    dc.rightsCreative Commons Attribution 3.0 Unported Licence*
    dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
    dc.titleCovalent modification of iron oxide-poly(lithocholic acid) nanoparticles with folic acid or doxorubicin – an approach for enhanced cancer therapypl
    dc.typeArticlepl
    dc.rights.holderThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence.pl
    dc.rights.holder© 2025 The Author(s). Published by the Royal Society of Chemistrypl
    dc.identifier.doi10.1039/d4ra08830a-
    dc.description.EmailAgnieszka Z. Wilczewska: agawilcz@uwb.edu.plpl
    dc.description.EmailKarolina H. Markiewicz: k.markiewicz@uwb.edu.plpl
    dc.description.EmailKatarzyna Niemirowicz-Laskowska: katarzyna.niemirowicz@umb.edu.plpl
    dc.description.AffiliationDawid Szymczuk - Faculty of Chemistry, University of Bialystok; Doctoral School of Exact and Natural Sciences, University of Bialystokpl
    dc.description.AffiliationKarolina H. Markiewicz - Faculty of Chemistry, University of Bialystokpl
    dc.description.AffiliationKatarzyna Niemirowicz-Laskowska - Department of Experimental Pharmacology, Medical University of Bialystokpl
    dc.description.AffiliationDiana Sawicka - Department of Experimental Pharmacology, Medical University of Bialystokpl
    dc.description.AffiliationIwona Misztalewska-Turkowicz - Faculty of Chemistry, University of Bialystokpl
    dc.description.AffiliationHalina Car - Department of Experimental Pharmacology, Medical University of Bialystok; Department of Clinical Pharmacology, Medical University of Bialystokpl
    dc.description.AffiliationAgnieszka Z. Wilczewska - Faculty of Chemistry, University of Bialystokpl
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    dc.identifier.eissn2046-2069-
    dc.description.volume15pl
    dc.description.number18pl
    dc.description.firstpage14246pl
    dc.description.lastpage14258pl
    dc.identifier.citation2RSC Advancespl
    dc.identifier.orcid0000-0002-8225-3196-
    dc.identifier.orcid0000-0002-4857-0489-
    dc.identifier.orcidbrakorcid-
    dc.identifier.orcidbrakorcid-
    dc.identifier.orcid0000-0001-6191-6053-
    dc.identifier.orcidbrakorcid-
    dc.identifier.orcid0000-0001-8587-6711-
    Występuje w kolekcji(ach):Artykuły naukowe (WChem)

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