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http://hdl.handle.net/11320/18172| Tytuł: | PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity |
| Autorzy: | Jastrzębska, Izabella Mellea, Stefano Salerno, Valerio Grześ, Paweł Adam Siergiejczyk, Leszek Niemirowicz-Laskowska, Katarzyna Bucki, Robert Monti, Bonifacio Santi, Claudio |
| Słowa kluczowe: | steroids selenium antibacterial antibiofilm |
| Data wydania: | 2019 |
| Data dodania: | 8-kwi-2025 |
| Wydawca: | MDPI |
| Źródło: | International Journal of Molecular Sciences, 2019, Volume 20, Issue 9, 2121 |
| Abstrakt: | We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective a ording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation. |
| Afiliacja: | Izabella Jastrzębska - Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland Stefano Mellea - Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland Valerio Salerno - Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland Paweł Adam Grześ - Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland Leszek Siergiejczyk - Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland Katarzyna Niemirowicz-Laskowska - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, ul. Mickiewicza 2C, 15-222 Bialystok, Poland Robert Bucki - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, ul. Mickiewicza 2C, 15-222 Bialystok, Poland Bonifacio Monti - Group of Catalysis and Organic Green Chemistry–Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06132 Perugia, Italy Claudio Santi - Group of Catalysis and Organic Green Chemistry–Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06132 Perugia, Italy |
| E-mail: | Izabella Jastrzębska: i.jastrzebska@uwb.edu.pl Stefano Mellea: stefano.mellea@gmail.com Valerio Salerno: vale_1192@hotmail.it Paweł Adam Grześ: felolix@gmail.com Leszek Siergiejczyk: nmrbial@uwb.edu.pl Katarzyna Niemirowicz-Laskowska: katia146@wp.pl Robert Bucki: buckirobert@gmail.com Bonifacio Monti: bonifaciomonti@gmail.com Claudio Santi: claudio.santi@unipg.it |
| Sponsorzy: | This research was funded by National Science Center, Poland, grant number UMO-2015/17/B/ST5/02892. |
| Opis: | The authors would like to thank Erasmus + Program (SM and VS). The project was performed under the umbrella of “SeS Redox & Catalyst Network”. Part of the study was conducted with the use of equipment purchased by Medical University of Białystok as part of the RPOWP 2007-2013 funding, Priority I, Axis 1.1, contract No. UDA-RPPD.01.01.00-20-001/15-00 dated 26.06.2015. CS also thanks the inter-universities consortium C.I.N.M.P.I.S. |
| URI: | http://hdl.handle.net/11320/18172 |
| DOI: | 10.3390/ijms20092121 |
| ISSN: | 1422-0067 |
| metadata.dc.identifier.orcid: | brakorcid brakorcid brakorcid brakorcid brakorcid brakorcid 0000-0001-7664-9226 brakorcid 0000-0002-7698-8970 |
| Typ Dokumentu: | Article |
| metadata.dc.rights.uri: | http://creativecommons.org/licenses/by/4.0/ |
| Właściciel praw: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Występuje w kolekcji(ach): | Artykuły naukowe (WChem) |
Pliki w tej pozycji:
| Plik | Opis | Rozmiar | Format | |
|---|---|---|---|---|
| I_Jastrzebska_S_Mellea_V_Salerno_at_al_PhSeZnCl_in_the_Synthesis_of_Steroidal.pdf | 4,62 MB | Adobe PDF | Otwórz |
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