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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/18168
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    Pole DCWartośćJęzyk
    dc.contributor.authorWawrusiewicz-Kurylonek, Natalia-
    dc.contributor.authorGościk, Joanna-
    dc.contributor.authorChorąży, Monika-
    dc.contributor.authorSiewko, Katarzyna-
    dc.contributor.authorPosmyk, Renata-
    dc.contributor.authorZajkowska, Agata-
    dc.contributor.authorCitko, Anna-
    dc.contributor.authorMaciulewski, Rafał-
    dc.contributor.authorSzelachowska, Małgorzata-
    dc.contributor.authorMyśliwiec, Janusz-
    dc.contributor.authorJastrzębska, Izabella-
    dc.contributor.authorKułakowska, Alina-
    dc.contributor.authorKochanowicz, Jan-
    dc.contributor.authorKrętowski, Adam Jacek-
    dc.date.accessioned2025-04-04T07:39:28Z-
    dc.date.available2025-04-04T07:39:28Z-
    dc.date.issued2020-
    dc.identifier.citationImmunobiology, Volume 225, Issue 1, 2020, 151864pl
    dc.identifier.urihttp://hdl.handle.net/11320/18168-
    dc.description.abstractPurpose: Autoimmune diseases are a group of complex diseases localized in multiple organ systems, with a wide spectrum of symptoms and still unclear causes. The aim of the present study was to analyse a possible association of three autoimmune disabilities - Multiple sclerosis (MS), LADA diabetes and Graves’ disease (GD) with single nucleotide polymorphism (SNP; rs1990760) in the IF IH1 gene (also known as a melanoma differentiation-associated protein 5 - MDA5) within the Polish population. An additional goal was also to look for a correlation between this polymorphism and different clinical patient-related factors. Materials and methods: The study population consisted of four groups of 944 unrelated Polish origin Caucasian patients – 324 with GD, 171 with MS, 49 with LADA diabetes and 400 healthy subjects as a control group. The SNP analysis was performed using the allelic discrimination technique. Results & Conclusions: There were significant associations of risk T allel of the analyzed polymorphism with all studied autoimmune diseases (GDeOR = 1.34, p = 7.02e-03; MSeOR = 1.36, p = 2.17e-02; LADA – OR = 3.36, p = 8.73e-07). We also found that the frequency of CT and TT genotypes of the rs1990760 IFIH1 gene only in females (with LADA, GD, MS) was significantly higher than those in the female control group (47%, 41% vs 44%, 34%; p = 1.32e-03, p = 4.39e-04; OR = 2.08, 95%CI: (1.33–3.28), OR = 2.29, 95% CI: (1.44–3.65) respectively). Our research has shown significant differences regarding some clinical features (BMI, TRAb, TSH, HbA1C, anti-GAD antibodies) and age at the beginning of the studied autoimmune disabilities. This study showed an association of rs1990760 polymorphism in the IFIH1 gene in the development of GD, LADA diabetes and MS within the Polish population. To our knowledge, this is the first study to investigate the relationship between IFIH1 polymorphisms and the risk of the development of MS and LADA in Poland.pl
    dc.language.isoenpl
    dc.publisherElsevierpl
    dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalpl
    dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/pl
    dc.subjectIFIH1 genepl
    dc.subjectGraves’ diseasepl
    dc.subjectMultiple sclerosispl
    dc.subjectLADA diabetespl
    dc.subjectPolymorphismpl
    dc.titleThe interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factorpl
    dc.typeArticlepl
    dc.rights.holder© 2019 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND licensepl
    dc.identifier.doi10.1016/j.imbio.2019.10.013-
    dc.description.EmailNatalia Wawrusiewicz-Kurylonek: natalia.wawrusiewicz-kurylonek@umb.edu.plpl
    dc.description.AffiliationNatalia Wawrusiewicz-Kurylonek - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationJoanna Gościk - Faculty of Computer Science Bialystok University of Technology, Wiejska 45A, 15-351 Bialystok, Polandpl
    dc.description.AffiliationMonika Chorąży - Department of Neurology, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationKatarzyna Siewko - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationRenata Posmyk - Department of Clinical Genetics, Medical University of Bialystok, Waszyngtona 14, 15-089, Bialystok, Polandpl
    dc.description.AffiliationAgata Zajkowska - Department of Neurology, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationAnna Citko - Clinical Research Centre, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationRafał Maciulewski - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationMałgorzata Szelachowska - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationJanusz Myśliwiec - Department of Nuclear Medicine, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationIzabella Jastrzębska - Faculty of Chemistry, University of Bialystok, Ciołkowskiego 1K, 15-245, Białystok, Polandpl
    dc.description.AffiliationAlina Kułakowska - Department of Neurology, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationJan Kochanowicz - Department of Neurology, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
    dc.description.AffiliationAdam Jacek Krętowski - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Poland; Clinical Research Centre, Medical University of Bialystok, Sklodowska – Curie 24A, 15-276, Bialystok, Polandpl
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    dc.identifier.eissn1878-3279-
    dc.description.volume225pl
    dc.description.issue1pl
    dc.identifier.citation2Immunobiologypl
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