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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16615
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    Pole DCWartośćJęzyk
    dc.contributor.authorPawelski, Damian-
    dc.contributor.authorWalewska, Alicja-
    dc.contributor.authorKsiezak, Sylwia-
    dc.contributor.authorSredzinski, Dariusz-
    dc.contributor.authorRadziwon, Piotr-
    dc.contributor.authorMoniuszko, Marcin-
    dc.contributor.authorGandusekar, Ramesh-
    dc.contributor.authorEljasiewicz, Andrzej-
    dc.contributor.authorŁaźny, Ryszard-
    dc.contributor.authorBrzeziński, Krzysztof-
    dc.contributor.authorPłońska-Brzezińska, Marta E.-
    dc.date.accessioned2024-06-05T08:42:49Z-
    dc.date.available2024-06-05T08:42:49Z-
    dc.date.issued2021-
    dc.identifier.citationInternational Journal of Molecular Sciences, Volume 22, Issue 21 (2021), p. 1-21pl
    dc.identifier.issn1422-0067-
    dc.identifier.urihttp://hdl.handle.net/11320/16615-
    dc.description.abstractCurcumin (CUR) is a natural compound that exhibits anti-inflammatory, anti-bacterial, and other biological properties. However, its application as an effective drug is problematic due to its poor oral bioavailability, solubility in water, and poor absorption from the gastrointestinal tract. The aim of this work is to synthesize monocarbonyl analogs of CUR based on the 9-methyl-9-azabicyclo[3.2.1]nonan-3-one (pseudopelletierine, granatanone) scaffold to improve its bioavailability. Granatane is a homologue of tropane, whose structure is present in numerous naturally occurring alkaloids, e.g., L-cocaine and L-scopolamine. In this study, ten new pseudopelletierine-derived monocarbonyl analogs of CUR were successfully synthesized and characterized by spectral methods and X-ray crystallography. Additionally, in vitro test of the cytotoxicity and anti-inflammatory properties of the synthesized compounds were performed.pl
    dc.description.sponsorshipThis research received no external funding. Ramesh Gandusekar was supported by funds from the “ImPRESS” project of the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 754432 and the Polish Ministry of Science and Higher Education through financial resources for science in 2018–2023 granted for the implementation of an international co-financed project.pl
    dc.language.isoenpl
    dc.publisherMDPIpl
    dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
    dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
    dc.subjectcurcuminpl
    dc.subjectpseudopelletierinepl
    dc.subjectgranatanonepl
    dc.subjectgranatanepl
    dc.subjectanti-inflammatory propertypl
    dc.subjectcytotoxicitypl
    dc.subjectcytokinespl
    dc.titleMonocarbonyl Analogs of Curcumin Based on the Pseudopelletierine Scaffold: Synthesis and Anti-Inflammatory Activitypl
    dc.typeArticlepl
    dc.rights.holderCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pl
    dc.identifier.doi10.3390/ijms222111384-
    dc.description.EmailDamian Pawelski: damian.pawelski@umb.edu.plpl
    dc.description.EmailAlicja Walewska: alicja.walewska@umb.edu.plpl
    dc.description.EmailSylwia Ksiezak: sylwia.ksiezak@icloud.compl
    dc.description.EmailDariusz Sredzinski: dsredzinski@rckik.bialystok.plpl
    dc.description.EmailPiotr Radziwon: piotr.radziwon@umb.edu.plpl
    dc.description.EmailMarcin Moniuszko: marcin.moniuszko@umb.edu.plpl
    dc.description.EmailRamesh Gandusekar: ramesh.gandusekar@umb.edu.plpl
    dc.description.EmailAndrzej Eljaszewicz: andrzej.eljaszewicz@umb.edu.plpl
    dc.description.EmailRyszard Łaźny: lazny@uwb.edu.plpl
    dc.description.EmailKrzysztof Brzezinski: kbrzezinski@ibch.poznan.plpl
    dc.description.EmailMarta E. Plonska-Brzezinska: marta.plonska-brzezinska@umb.edu.plpl
    dc.description.AffiliationDamian Pawelski - Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystokpl
    dc.description.AffiliationAlicja Walewska - Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystokpl
    dc.description.AffiliationSylwia Ksiezak - Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystokpl
    dc.description.AffiliationDariusz Sredzinski - Regional Blood Donation and Blood Treatment Center in Bialystokpl
    dc.description.AffiliationPiotr Radziwon - Regional Blood Donation and Blood Treatment Center in Bialystok; Department of Hematology, Medical University of Bialystokpl
    dc.description.AffiliationMarcin Moniuszko - Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok; Department of Allergology and Internal Medicine, Medical University of Bialystokpl
    dc.description.AffiliationRamesh Gandusekar - Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystokpl
    dc.description.AffiliationAndrzej Eljaszewicz - Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystokpl
    dc.description.AffiliationRyszard Łaźny - Faculty of Chemistry, University of Bialystokpl
    dc.description.AffiliationKrzysztof Brzezinski - Department of Structural Biology of Prokaryotic Organisms, Institute of Bioorganic Chemistry, Polish Academy of Sciencespl
    dc.description.AffiliationMarta E. Plonska-Brzezinska - Department of Organic Chemistry, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystokpl
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    dc.identifier.citation2International Journal of Molecular Sciencespl
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