REPOZYTORIUM UNIWERSYTETU
W BIAŁYMSTOKU
UwB

  1. Repozytorium Uniwersytetu w Białymstoku
  2. Wydział Chemii / Faculty of Chemistry
  3. Artykuły naukowe (WChem)

Szukanie zaawansowane
  • Zespoły i Kolekcje


  • Zaloguj się
  • Zarejestruj się
  • Mój RUB
  • FAQ
  • Polityka
  • Regulamin
  • DOI
  • Instrukcja
  • Aspekty prawne
  • Open Access
  • Archiwum


  • Kontakt
  • O Dspace
  • Strona Biblioteki
  • Strona Uczelni



    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16607
    Pełny rekord metadanych
    Pole DCWartośćJęzyk
    dc.contributor.authorPotaś, Joanna-
    dc.contributor.authorWilczewska, Agnieszka Zofia-
    dc.contributor.authorMisiak, Paweł-
    dc.contributor.authorBasa, Anna-
    dc.contributor.authorWinnicka, Katarzyna-
    dc.date.accessioned2024-06-04T10:35:30Z-
    dc.date.available2024-06-04T10:35:30Z-
    dc.date.issued2022-
    dc.identifier.citationInternational Journal of Molecular Sciences, Vol. 23, Issue 15 (2022), p. 1-18pl
    dc.identifier.issn1422-0067-
    dc.identifier.urihttp://hdl.handle.net/11320/16607-
    dc.description.abstractPolyelectrolyte multilayers (PEMs) based on polyelectrolyte complex (PEC) structures are recognized as interesting materials for manufacturing functionalized coatings or drug delivery platforms. Difficulties in homogeneous PEC system development generated the idea of chitosan (CS)/low-methoxy amidated pectin (LM PC) multilayer film optimization with regard to the selected variables: the polymer ratio, PC type, and order of polymer mixing. Films were formulated by solvent casting method and then tested to characterize CS/LM PC PECs, using thermal analysis, Fourier transform infrared spectroscopy (FTIR), turbidity, and zeta potential measurements. The internal structure of the films was visualized by using scanning electron microscopy. Analysis of the mechanical and swelling properties enabled us to select the most promising formulations with high uniformity and mechanical strength. Films with confirmed multilayer architecture were indicated as a promising material for the multifunctional systems development for buccal drug delivery. They were also characterized by improved thermal stability as compared to the single polymers and their physical mixtures, most probably as a result of the CS–LM PC interactions. This also might indicate the potential protective effect on the active substances being incorporated in the PEC-based films.pl
    dc.description.sponsorshipThis research was funded by Medical University of Bialystok (project number: SUB/2/DN/22/002/2215).pl
    dc.language.isoenpl
    dc.publisherMDPIpl
    dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
    dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
    dc.subjectpolyelectrolyte complexpl
    dc.subjectpolyelectrolyte multilayerpl
    dc.subjectchitosanpl
    dc.subjectpectinpl
    dc.subjectbuccal drug delivery materialspl
    dc.titleOptimization of Multilayer Films Composed of Chitosan and Low-Methoxy Amidated Pectin as Multifunctional Biomaterials for Drug Deliverypl
    dc.typeArticlepl
    dc.rights.holderCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pl
    dc.identifier.doi10.3390/ijms23158092-
    dc.description.EmailJoanna Potaś: joanna.potas@umb.edu.plpl
    dc.description.EmailAgnieszka Zofia Wilczewska: agawilcz@uwb.edu.plpl
    dc.description.EmailPaweł Misiak: p.misiak@uwb.edu.plpl
    dc.description.EmailAnna Basa: abasa@uwb.edu.plpl
    dc.description.EmailKatarzyna Winnicka: kwin@umb.edu.plpl
    dc.description.AffiliationJoanna Potaś - Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, Polandpl
    dc.description.AffiliationAgnieszka Zofia Wilczewska - Department of Polymers and Organic Synthesis, Faculty of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Polandpl
    dc.description.AffiliationPaweł Misiak - Department of Polymers and Organic Synthesis, Faculty of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Polandpl
    dc.description.AffiliationAnna Basa - Department of Physical Chemistry, Faculty of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland; abasa@uwb.edu.plpl
    dc.description.AffiliationKatarzyna Winnicka - Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, Polandpl
    dc.description.referencesPotaś, J.; Winnicka, K. The Potential of polyelectrolyte multilayer films as drug delivery materials. Int. J. Mol. Sci. 2022, 23, 3496.pl
    dc.description.referencesZhao, S.; Caruso, F.; Dähne, L.; Decher, G.; De Geest, B.G.; Fan, J.; Feliu, N.; Gogotsi, Y.; Hammond, P.T.; Hersam, M.C.; et al. The future of layer-by-layer assembly: A tribute to ACS nano associate editor Helmuth Möhwald. ACS Nano 2019, 13, 6151–6169.pl
    dc.description.referencesCriado-Gonzalez, M.; Mijangos, C.; Hernández, R. Polyelectrolyte multilayer films based on natural polymers: From fundamentals to bio-applications. Polymers 2021, 13, 2254.pl
    dc.description.referencesGamzazade, A.I.; Nasibov, S.M. Formation and properties of polyelectrolyte complexes of chitosan hydrochloride and sodium dextransulfate. Carbohydr. Polym. 2002, 50, 339–343.pl
    dc.description.referencesMeka, V.S.; Sing, M.K.G.; Pichika, M.R.; Nali, S.R.; Kolapall, V.R.M.; Kesharwani, P. A comprehensive review on polyelectrolyte complexes. Drug Discov. Today 2017, 22, 1697–1706.pl
    dc.description.referencesMagoń, M.S. Layered polyelectrolyte complexes: Physics of formation and molecular properties. J. Phys. Condens. Matter. 2003, 15, 1781–1808.pl
    dc.description.referencesMontenegro-Nicolini, M.; Morales, J.O. Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics. AAPS PharmSciTech 2017, 18, 3–14.pl
    dc.description.referencesChollakup, R.; Smitthipong, W.; Eisenbach, C.; Tirrell, M. Phase behavior and coacervation of aqueous poly(acrylic acid)-poly(allylamine) solutions. Macromolecules 2010, 43, 2518–2528.pl
    dc.description.referencesAranaz, I.; Mengibar, M.; Harris, R.; Panos, I.; Miralles, B.; Acosta, N.; Galed, G.; Heras, A. Functional characterization of chitin and chitosan. Curr. Chem. Biol. 2009, 3, 203–230.pl
    dc.description.referencesKumar, A.; Vimal, A.; Kumar, A. Why Chitosan? From properties to perspective of mucosal drug delivery. Int. J. Biol. Macromol. 2016, 91, 615–622.pl
    dc.description.referencesHosseinnejad, M.; Jafari, S.M. Evaluation of different factors affecting antimicrobial properties of chitosan. Int. J. Biol. Macromol. 2016, 85, 467–475.pl
    dc.description.referencesKim, I.Y.; Seo, S.J.; Moon, H.S.; Yoo, M.K.; Park, I.Y.; Kim, B.C.; Cho, C.S. Chitosan and its derivatives for tissue engineering applications. Biotechnol. Adv. 2008, 26, 1–21.pl
    dc.description.referencesSundar-Raj, A.A.; Rubila, S.; Jayabalan, R.; Ranganathan, T.V. A review on pectin: Chemistry due to general properties of pectin and its pharmaceutical uses. Sci. Rep. 2012, 1, 550–553.pl
    dc.description.referencesCao, L.; Lu, W.; Mata, A.; Nishinari, K.; Fang, Y. Egg-box model-based gelation of alginate and pectin: A review. Carbohydr. Polym. 2020, 242, 116389.pl
    dc.description.referencesNižić, L.; Potaś, J.;Winnicka, K.; Szekalska, M.; Erak, I.; Gretić, M.; Jug, M.; Hafner, A. Development, characterisation and nasal deposition of melatonin-loaded pectin/hypromellose microspheres. Eur. J. Pharm. Sci. 2020, 141, 105115.pl
    dc.description.referencesJug, M.; Kosalec, I.; Maestrelli, F.; Mura, P. Development of low methoxy amidated pectin—Based mucoadhesive patches for buccal delivery of triclosan: Effect of cyclodextrin complexation. Carbohydr. Polym. 2012, 90, 1794–1803.pl
    dc.description.referencesLi, D.; Li, J.; Dong, H.; Li, X.; Zhang, J.; Ramaswamy, S.; Xu, F. Pectin in biomedical and drug delivery applications: A review. Int. J. Biol; Macromol. 2021, 185, 49–65.pl
    dc.description.referencesMurata, Y.; Maida, C.; Kofuji, K. Drug release profiles and disintegration properties of pectin films. Materials 2019, 12, 355.pl
    dc.description.referencesAkhgari, A.; Farahmand, F.; Afrasiabi Garekani, H.; Sadeghi, F.; Vandamme, T. The effect of pectin on swelling and permeability characteristics of free films containing Eudragit RL and/or RS as a coating formulation aimed for colonic drug delivery. Daru 2010, 18, 91–96.pl
    dc.description.referencesSingh, S.; Jain, S.; Muthu, M.S.; Tiwari, S.; Tilak, R. Preparation and evaluation of buccal bioadhesive films containing clotrimazole. AAPS Pharm. Sci. Tech. 2008, 9, 660–667.pl
    dc.description.referencesTejada, G.; Barrera, M.G.; Piccirilli, G.N.; Sortino, M.; Frattini, A.; Salomón, C.J.; Lamas, M.C.; Leonardi, D. Development and evaluation of buccal films based on chitosan for the potential treatment of oral candidiasis. AAPS Pharm. Sci. Tech. 2017, 18, 936–946.pl
    dc.description.referencesKean, T.; Thanou, M. Biodegradation, biodistribution and toxicity of chitosan. Adv. Drug Deliv. Rev. 2010, 62, 3–11.pl
    dc.description.referencesPotaś, J.; Szymańska, E.; Basa, A.; Hafner, A.; Winnicka, K. Tragacanth gum/chitosan polyelectrolyte complexes-based hydrogels enriched with xanthan gum as promising materials for buccal application. Materials 2021, 14, 86.pl
    dc.description.referencesPotaś, J.; Szymańska, E.; Wróblewska, M.; Kurowska, I.; Maciejczyk, M.; Basa, A.; Wolska, E.; Wilczewska, A.Z.; Winnicka, K. Multilayer films based on chitosan/pectin polyelectrolyte complexes as novel platforms for buccal administration of clotrimazole. Pharmaceutics 2021, 13, 1588.pl
    dc.description.referencesRajaram, D.M.; Laxman, S.D. Buccal mucoadhesive films: A review. Sys. Rev. Pharm. 2017, 8, 31–38.pl
    dc.description.referencesNair, A.B.; Kumria, R.; Harsha, S.; Attimarad, M.; Al-Dhubiab, B.E.; Alhaider, I.A. In vitro techniques to evaluate buccal films. J. Control. Release 2013, 166, 10–21.pl
    dc.description.referencesCentkowska, K.; Ławrecka, E.; Sznitowska, M. Technology of orodispersible polymer films with micronized loratadine-influence of different drug loadings on film properties. Pharmaceutics 2020, 12, 250.pl
    dc.description.referencesMishra, R.; Soni, K.; Mehta, T. Mucoadhesive vaginal film of fluconazole using cross-linked chitosan and pectin. J. Therm. Anal. Calorim. 2017, 130, 1683–1695.pl
    dc.description.referencesTejada, G.; Piccirilli, G.N.; Sortino, M.; Salomón, C.J.; Lamas, M.C.; Leonardi, D. Formulation and in vitro efficacy of antifungal mucoadhesive polymeric matrices for the delivery of miconazole nitrate. Mater. Sci. Eng. C 2017, 79, 140–150.pl
    dc.description.referencesSaporito, F.; Sandri, G.; Rossi, S.; Bonferoni, M.C.; Riva, F.; Malavasi, L.; Caramella, C.; Ferrari, F. Freeze dried chitosan acetate dressings with glycosaminoglycans and tranexamic acid. Carbohydr. Polym. 2018, 184, 408–417.pl
    dc.description.referencesSakloetsakun, D.; Preechagoon, D.; Bernkop-Schnürch, A.; Pongjanyakul, T. Chitosan-gum arabic polyelectrolyte complex films: Physicochemical, mechanical and mucoadhesive properties. Pharm. Dev. Technol. 2016, 21, 590–599.pl
    dc.description.referencesAbruzzo, F.; Bigucci, T.; Cerchiara, B.; Saladini, M.C.; Gallucci, F.; Cruciani, B.; Vitali, B. Luppi, Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate. Carbohydr. Polym. 2013, 91, 651–658.pl
    dc.description.referencesKononova, S.V.; Kruchinina, E.V.; Petrova, V.A.; Baklagina, Y.G.; Klechkovskaya, V.V.; Orekhov, A.S.; Vlasova, E.N.; Popova, E.N.; Gubanova, G.N.; Skorik, Y.A. Pervaporation membranes of a simplex type with polyelectrolyte layers of chitosan and sodium hyaluronate. Carbohydr Polym. 2019, 209, 10–19.pl
    dc.description.referencesSchlenoff, J.B.; Rmaile, A.H.; Bucur, C.B. Hydration contributions to association in polyelectrolyte multilayers and complexes: Visualizing hydrophobicity. J. Am. Chem. Soc. 2008, 130, 13589–13597.pl
    dc.description.referencesFares, H.M.; Schlenoff, J.B. Diffusion of sites versus polymers in polyelectrolyte complexes and multilayers. J. Am. Chem. Soc. 2017, 139, 14656–14667.pl
    dc.description.referencesde Souza, R.F.B.; de Souza, F.C.B.; Moraes, A.M. Analysis of the performance of polysaccharide membranes in aqueous media as a tool to assist wound-dressing selection. J. Appl. Polym. Sci. 2017, 134, 45386–45397.pl
    dc.description.referencesChabala, L.F.G.; Cuartas, C.E.E.; López, M.E.L. Release behavior and antibacterial activity of chitosan/alginate blends with Aloe vera and silver nanoparticles. Mar. Drugs 2017, 15, 328.pl
    dc.description.referencesKassem, A.A.; Ismail, F.A.; Naggar, V.F.; Aboulmagd, E. Preparation and evaluation of periodontal films based on polyelectrolyte complex formation. Pharm. Dev. Technol. 2014, 20, 297–305.pl
    dc.description.referencesGhaffari, A.; Navaee, K.; Oskoui, M.; Bayati, K.; Rafiee-Tehrani, M. Preparation and characterization of free mixed-film of pectin/chitosan/Eudragit((R)) RS intended for sigmoidal drug delivery. Eur. J. Pharm. Biopharm. 2007, 67, 175–186. [CrossRef]pl
    dc.description.referencesNeufeld, L.; Bianco-Peled, H. Pectin-chitosan physical hydrogels as potential drug delivery vehicles. Int. J. Biol. Macromol. 2017, 101, 852–861.pl
    dc.description.referencesMura, C.; Nácher, A.; Merino, V.; Merino-Sanjuan, M.; Carda, C.; Ruiz, A.; Manconi, M.; Loy, G.; Fadda, A.M.; Diez-Sales, O. N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: In vivo study with TNBS-induced colitis model in rats. Int. J. Pharm. 2011, 416, 145–154.pl
    dc.description.referencesMahbubul, I.M. 3-stability and dispersion characterization of nanofluid. In Micro and Nano Technologies, Preparation, Characterization, Properties and Application of Nanofluid; Mahbubul, I.M., Ed.;William Andrew Publishing: Norwich, NY, USA, 2019; pp. 47–112.pl
    dc.description.referencesMaciel, V.B.V.; Yoshida, C.M.P.; Franco, T.T. Chitosan/pectin polyelectrolyte complex as a pH indicator. Carbohydr. Polym. 2015, 132, 537–545.pl
    dc.description.referencesUnited States Pharmacopoeial Convention. United States Pharmacopoeia and National Formulary (USP 41—NF 36); United States Pharmacopoeial Convention: Rockville, MD, USA, 2016.pl
    dc.description.referencesYüksel, N.; Dinç, E.; Onur, F.; Baykara, T. Influence of swelling degree on release of nicardipine hydrochloride from acrylic microspheres prepared by solvent evaporation method. Pharm. Dev. Technol. 1998, 3, 115–121.pl
    dc.description.referencesStrand, A.; Vähäsalo, L.; Ketola, A.; Salminen, K.; Retulainen, E.; Sundberg, A. In-situ analysis of polyelectrolyte complexes by flow cytometry. Cellulose 2018, 25, 3781–3795.pl
    dc.description.referencesJeganathan, B.; Prakya, V.; Deshmukh, A. Preparation and evaluation of diclofenac sodium tablet coated with polyelectrolyte multilayer film using hypromellose acetate succinate and polymethacrylates for pH-dependent, modified release drug delivery. AAPS PharmSciTech 2016, 17, 578–587.pl
    dc.description.firstpage1pl
    dc.description.lastpage18pl
    dc.identifier.citation2International Journal of Molecular Sciencespl
    dc.identifier.orcid0000-0001-9233-1330-
    dc.identifier.orcid0000-0001-8587-6711-
    dc.identifier.orcid0000-0002-6882-3519-
    dc.identifier.orcid0000-0003-2331-1779-
    dc.identifier.orcid0000-0002-1013-610X-
    Występuje w kolekcji(ach):Artykuły naukowe (WChem)

    Pliki w tej pozycji:
    Plik Opis RozmiarFormat 
    J_Potas_AZ_Wilczewska_P_Misiak_at_al_Optimization_of_Multilayer_Films_Composed.pdf3,31 MBAdobe PDFOtwórz
    Pokaż uproszczony widok rekordu Zobacz statystyki


    Pozycja ta dostępna jest na podstawie licencji Licencja Creative Commons CCL Creative Commons