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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16606
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    Pole DCWartośćJęzyk
    dc.contributor.authorWilczewska, Agnieszka Z.-
    dc.contributor.authorNiemirowicz - Laskowska, Katarzyna-
    dc.contributor.authorMarkiewicz, Karolina H.-
    dc.contributor.authorMisztalewska - Turkowicz, Iwona-
    dc.contributor.authorDudź, Ewelina-
    dc.contributor.authorMilewska, Sylwia-
    dc.contributor.authorMisiak, Paweł-
    dc.contributor.authorKurowska, Izabela-
    dc.contributor.authorSadowska, Anna-
    dc.contributor.authorCar, Halina-
    dc.contributor.authorSiemiaszko, Gabriela-
    dc.date.accessioned2024-06-04T10:33:15Z-
    dc.date.available2024-06-04T10:33:15Z-
    dc.date.issued2021-
    dc.identifier.citationCancer Nanotechnology, Volume 12 (2021), p. 1-24pl
    dc.identifier.issn1868-6966-
    dc.identifier.urihttp://hdl.handle.net/11320/16606-
    dc.description.abstractBackground: In recent years, targeted drug delivery strategies have received special attention from the scientifc world due to advantages such as more efective therapy and reduction of side efects. The principle of operation is delayed excretion from the bloodstream of the drug delivery system compared to the drug itself, as well as facilitated penetration into diseased cells thanks to the use of ligands recognized by appropriate receptors. Particularly interesting drug carriers are amphiphilic copolymers that form nano-sized micelles with a drug, which can release the drug at a specifc place in the body under the infuence of appropriate stimuli. Results: We describe the synthesis of the diblock polymer, poly(2-hydroxyethyl acrylate)-b-poly(N-vinylcaprolactam) using RAFT/MADIX (Reversible Addition-Fragmentation chain Transfer/MAcromolecular Design by Interchange of Xanthate) controlled polymerization afording polymers with good dispersity according to SEC (Size-Exclusion Chromatography). Some post-modifcations of the polymer with folic acid were then performed as evidenced by NMR (Nuclear Magnetic Resonance), UV–Vis (UltraViolet–Visible) and FT-IR (Fourier-Transform Infrared) spectroscopy, and TGA (ThermoGravimetricAnalysis). The formation of stable micellar systems from polymers with and without the drug, 5-fuorouracil, was confrmed by DLS (Dynamic Light Scattering) and zeta potential measurements, and TEM (Transmission Eelectron Microscopy) imaging. Finally, the cloud point of the polymers was investigated, which turned out to be close to the temperature of the human body. Most importantly, these micellar systems have been explored as a drug delivery system against colon cancer, showing increased cytotoxicity compared to the drug alone. This efect was achieved due to the easier cellular uptake by the interaction of folic acid and its receptors on the surface of cancer cells. Conclusions: The presented results constitute a solid foundation for the implementation of a nano-sized drug delivery system containing folic acid for practical use in the treatment of drug-resistant cancer, as well as more efective therapy with fewer side efects.pl
    dc.description.sponsorshipThis work was fnancially supported by the National Science Centre, Poland, grant no. NCN/2016/21/B/ST5/01365 (AZW). Analyses were performed in the Centre of Synthesis and Analysis BioNanoTechno of the University of Bialystok. The equipment in the Centre was funded by the EU as a part of the Operational Program Development of Eastern Poland 2007–2013, projects: POPW.01.03.00-20-034/09-00 and POPW.01.03.00-20-004/11.pl
    dc.language.isoenpl
    dc.publisherBMCpl
    dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
    dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
    dc.subjectFolic acidpl
    dc.subjectColon cancerpl
    dc.subject5-Fluorouracilpl
    dc.subjectDrug delivery systempl
    dc.subjectTargeted therapypl
    dc.subjectRAFT/MADIX polymerizationpl
    dc.subjectPolymeric micellespl
    dc.subjectThermoresponsive polymerpl
    dc.titleSynergistic effect of folate-conjugated thermosensitive polymers and 5-fluorouracil in the treatment of colon cancerpl
    dc.typeArticlepl
    dc.rights.holder© The Author(s), 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.pl
    dc.identifier.doi10.1186/s12645-021-00104-9-
    dc.description.AffiliationGabriela Siemiaszko - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Bialystok, Polandpl
    dc.description.AffiliationKatarzyna Niemirowicz‑Laskowska - Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15‑361 Bialystok, Polandpl
    dc.description.AffiliationKarolina H. Markiewicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Bialystok, Polandpl
    dc.description.AffiliationIwona Misztalewska‑Turkowicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Bialystok, Polandpl
    dc.description.AffiliationEwelina Dudź - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Bialystok, Polandpl
    dc.description.AffiliationSylwia Milewska - Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15‑361 Bialystok, Polandpl
    dc.description.AffiliationPaweł Misiak - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Bialystok, Polandpl
    dc.description.AffiliationIzabela Kurowska - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Bialystok, Polandpl
    dc.description.AffiliationAnna Sadowska - Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15‑361 Bialystok, Polandpl
    dc.description.AffiliationHalina Car - Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15‑361 Bialystok, Polandpl
    dc.description.AffiliationAgnieszka Z. Wilczewska - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15‑245 Bialystok, Polandpl
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    dc.description.volume12pl
    dc.description.firstpage1pl
    dc.description.lastpage24pl
    dc.identifier.citation2Cancer Nanotechnologypl
    dc.identifier.orcid0000-0001-8587-6711-
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