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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16604
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    Pole DCWartośćJęzyk
    dc.contributor.authorNiemirowicz-Laskowska, Katarzyna-
    dc.contributor.authorGłuszek, Katarzyna-
    dc.contributor.authorPiktel, Ewelina-
    dc.contributor.authorPajuste, Karlis-
    dc.contributor.authorDurnaś, Bonita-
    dc.contributor.authorKról, Grzegorz-
    dc.contributor.authorWilczewska, Agnieszka Z.-
    dc.contributor.authorJanmey, Paul A.-
    dc.contributor.authorPlotniece, Aiva-
    dc.contributor.authorBucki, Robert-
    dc.date.accessioned2024-06-04T09:56:10Z-
    dc.date.available2024-06-04T09:56:10Z-
    dc.date.issued2018-
    dc.identifier.citationInternational Journal of Nanomedicine, Volume 13, 2018, p. 3411–3424pl
    dc.identifier.issn1178-2013-
    dc.identifier.urihttp://hdl.handle.net/11320/16604-
    dc.description.abstractBackground: 1,4-Dihydropyridine (1,4-DHP) and its derivatives are well-known calcium channel blockers with antiarrhythmic and antihypertensive activities. These compounds exhibit pleiotropic effects including antimicrobial activities that rely on their positive charge and amphipathic nature. Use of magnetic nanoparticles (MNPs) as carriers of 1,4-DHP modulates their properties and enables improved formulations with higher efficacy and less toxicity. Methods: In this study, the antimicrobial and immunomodulatory activities of novel 1,4-DHP derivatives in free form and immobilized on MNPs were determined by evaluating pathogen outgrowth and proinflammatory cytokine release in experimental settings that involve incubation of various 1,4-DHPs with clinical isolates of bacteria or fungi as well as mammalian cell culture models. Results: Conventional immobilization of 1,4-DHP on aminosilane-coated MNPs markedly enhances their antimicrobial activity compared to nonimmobilized molecules, in part because of the higher affinity of these nanosystems for bacterial cell wall components in the presence of human body fluids. Conclusion: Optimized nanosystems are characterized by improved biocompatibility and higher anti-inflammatory properties that provide new opportunities for the therapy of infectious diseasespl
    dc.description.sponsorshipThis study was supported by the National Science Center, Poland, under grant UMO-2015/17/B/NZ6/03473 (to RB). In 2016, KN-L was awarded a fellowship from the Foundation for Polish Science (FNP). This study was conducted with the use of equipment purchased by the Medical University of Białystok as a part of the RPOWP 2007–2013 funding, Priority I, Axis 1.1, contract no UDA-RPPD.01.01.00-20-001/15-00 dated June 26, 2015.pl
    dc.language.isoenpl
    dc.publisherDove Presspl
    dc.rightsUznanie autorstwa-Użycie niekomercyjne 4.0 Międzynarodowe*
    dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
    dc.subjectmagnetic nanoparticlespl
    dc.subject1,4-dihydropyridinepl
    dc.subjectantibacterialpl
    dc.subjectantifungalpl
    dc.subjectimmunomodulatory propertiespl
    dc.titleBactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridinespl
    dc.typeArticlepl
    dc.rights.holder© 2018 Niemirowicz-Laskowska et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).pl
    dc.identifier.doi10.2147/IJN.S157564-
    dc.description.EmailRobert Bucki: buckirobert@gmail.compl
    dc.description.AffiliationKatarzyna Niemirowicz-Laskowska - Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystokpl
    dc.description.AffiliationKatarzyna Głuszek - Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystokpl
    dc.description.AffiliationEwelina Piktel - Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystokpl
    dc.description.AffiliationKarlis Pajuste - Laboratory of Membrane Active Compounds and β-Diketones, Latvian Institute of Organic Synthesis, Riga, Latviapl
    dc.description.AffiliationBonita Durnaś - Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielcepl
    dc.description.AffiliationGrzegorz Król - Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielcepl
    dc.description.AffiliationAgnieszka Z. Wilczewska - Institute of Chemistry, University of Bialystokpl
    dc.description.AffiliationPaul A Janmey - Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvaniapl
    dc.description.AffiliationAiva Plotniece - Laboratory of Membrane Active Compounds and β-Diketones, Latvian Institute of Organic Synthesis, Riga, Latviapl
    dc.description.AffiliationRobert Bucki - Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystokpl
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    dc.description.volume13pl
    dc.description.firstpage3411pl
    dc.description.lastpage3424pl
    dc.identifier.citation2International Journal of Nanomedicinepl
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