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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16597
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    Pole DCWartośćJęzyk
    dc.contributor.authorTokajuk, Grażyna-
    dc.contributor.authorNiemirowicz, Katarzyna-
    dc.contributor.authorDeptuła, Piotr-
    dc.contributor.authorPiktel, Ewelina-
    dc.contributor.authorCieśluk, Mateusz-
    dc.contributor.authorWilczewska, Agnieszka Z.-
    dc.contributor.authorDąbrowski, Jan R.-
    dc.contributor.authorBucki, Robert-
    dc.date.accessioned2024-06-03T09:00:30Z-
    dc.date.available2024-06-03T09:00:30Z-
    dc.date.issued2017-
    dc.identifier.citationInternational Journal of Nanomedicine, Volume 12, 2017, p. 7833–7846pl
    dc.identifier.issn1178-2013-
    dc.identifier.urihttp://hdl.handle.net/11320/16597-
    dc.description.abstractNanotechnology offers new tools for developing therapies to prevent and treat oral infections, particularly biofilm-dependent disorders, such as dental plaques and endodontic and periodontal diseases. Chlorhexidine (CHX) is a well-characterized antiseptic agent used in dentistry with broad spectrum activity. However, its application is limited due to inactivation in body fluid and cytotoxicity toward human cells, particularly at high concentrations. To overcome these limitations, we synthesized nanosystems composed of aminosilane-coated magnetic nanoparticles functionalized with chlorhexidine (MNP@CHX). In the presence of human saliva, MNPs@ CHX displayed significantly greater bactericidal and fungicidal activity against planktonic and biofilm-forming microorganisms than free CHX. In addition, CHX attached to MNPs has an increased ability to restrict the growth of mixed-species biofilms compared to free CHX. The observed depolarization of mitochondria in fungal cells treated with MNP@CHX suggests that induction of oxidative stress and oxidation of fungal structures may be a part of the mechanism responsible for pathogen killing. Nanoparticles functionalized by CHX did not affect host cell proliferation or their ability to release the proinflammatory cytokine, IL-8. The use of MNPs as a carrier of CHX has great potential for the development of antiseptic nanosystems.pl
    dc.description.sponsorshipThis work was supported by the National Science Center, Poland, under grant UMO-2014/15/D/NZ6/02665 (to KN). In 2016, KN was awarded a fellowship from the Foundation for Polish Science. This study was conducted with the use of equipment purchased by the Medical University of Białystok as part of the RPOWP 2007–2013 funding, Priority I, Axis 1.1, contract number UDA-RPPD.01.01.00-20-001/15-00, dated 26.06.2015.pl
    dc.language.isoenpl
    dc.publisherDove Presspl
    dc.rightsUznanie autorstwa-Użycie niekomercyjne 4.0 Międzynarodowe*
    dc.rights.uricreativecommons.org/licenses/by-nc/3.0/*
    dc.subjectchlorhexidinepl
    dc.subjectmagnetic nanoparticlespl
    dc.subjectantimicrobial propertiespl
    dc.subjectanti-biofilmpl
    dc.titleUse of magnetic nanoparticles as a drug delivery system to improve chlorohexidine antimicrobial activitypl
    dc.typeArticlepl
    dc.rights.holder© 2017 Tokajuk et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).pl
    dc.identifier.doi10.2147/IJN.S140661-
    dc.description.AffiliationGrażyna Tokajuk - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok; Department of Intergrated Dentistry, Medical University of Białystokpl
    dc.description.AffiliationKatarzyna Niemirowicz - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystokpl
    dc.description.AffiliationPiotr Deptuła - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok; Department of Materials and Biomedical Engineering, Białystok University of Technologypl
    dc.description.AffiliationEwelina Piktel - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystokpl
    dc.description.AffiliationMateusz Cieśluk - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystokpl
    dc.description.AffiliationAgnieszka Z. Wilczewska - Institute of Chemistry, University of Białystok, Białystok, Polandpl
    dc.description.AffiliationJan R. Dąbrowski - Department of Materials and Biomedical Engineering, Białystok University of Technologypl
    dc.description.AffiliationRobert Bucki - Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystokpl
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    dc.description.volume12pl
    dc.description.firstpage7833pl
    dc.description.lastpage7846pl
    dc.identifier.citation2International Journal of Nanomedicinepl
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