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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16593
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    Pole DCWartośćJęzyk
    dc.contributor.authorKurowska, Izabela-
    dc.contributor.authorMarkiewicz, Karolina H.-
    dc.contributor.authorNiemirowicz-Laskowska, Katarzyna-
    dc.contributor.authorDestarac, Mathias-
    dc.contributor.authorWielgat, Przemysław-
    dc.contributor.authorMisztalewska-Turkowicz, Iwona-
    dc.contributor.authorMisiak, Paweł-
    dc.contributor.authorCar, Halina-
    dc.contributor.authorWilczewska, Agnieszka Z.-
    dc.date.accessioned2024-06-03T07:11:43Z-
    dc.date.available2024-06-03T07:11:43Z-
    dc.date.issued2023-
    dc.identifier.citationBiomacromolecules 2023, Vol. 24 (11), p. 4854−4868pl
    dc.identifier.issn1525-7797-
    dc.identifier.urihttp://hdl.handle.net/11320/16593-
    dc.description.abstractHerein, we report the formation of drug delivery systems from original thermoresponsive block copolymers containing lipid-based segments. Two acrylate monomers derived from palmitic- or oleic-acid−based diacylglycerols (DAGs) were synthesized and polymerized by the reversible addition−fragmentation chain transfer (RAFT) method. Well-defined DAG-based polymers with targeted molar masses and narrow molar mass distributions were next used as macro-chain transfer agents (macroCTAs) for the polymerization of N-isopropylacrylamide (NIPAAm) or N-vinylcaprolactam (NVCL). The obtained amphiphilic block copolymers were formed into polymeric nanoparticles (PNPs) with and without encapsulated doxorubicin and characterized. Their biological assessment indicated appropriate cytocompatibility with the representatives of normal cells. Furthermore, compared to the free drug, increased cytotoxicity and apoptosis or necrosis induction in breast cancer cells was documented, including a highly aggressive and invasive triple-negative MDA-MB-231 cell line.pl
    dc.description.sponsorshipThis work was financially supported by the National Science Centre, Poland, grant no. NCN/2019/35/B/ST5/03391 (A.Z.W.). Analyses were performed in the Centre of Synthesis and Analysis BioNanoTechno of the University of Bialystok. The equipment in the Centre was funded by the EU as a part of the Operational Program Development of Eastern Poland 2007−2013, projects: POPW.01.03.00-20-034/09-00 and POPW.01.03.00-20-004/11. The biological part was performed at the Medical University of Bialystok SUB/1/DN/22/002/3327 (K.N.L.).pl
    dc.language.isoenpl
    dc.publisherACS Publicationspl
    dc.rightsUznanie autorstwa 4.0 Międzynarodowe*
    dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
    dc.titleMembrane-Active Thermoresponsive Block Copolymers Containing a Diacylglycerol-Based Segment: RAFT Synthesis, Doxorubicin Encapsulation, and Evaluation of Cytotoxicity against Breast Cancer Cellspl
    dc.typeArticlepl
    dc.rights.holderThis article is licensed under CC-BY 4.0pl
    dc.identifier.doi10.1021/acs.biomac.3c00580-
    dc.description.EmailKarolina H. Markiewicz: k.markiewicz@uwb.edu.plpl
    dc.description.EmailAgnieszka Z. Wilczewska: agawilcz@uwb.edu.plpl
    dc.description.AffiliationIzabela Kurowska - Faculty of Chemistry, University of Bialystokpl
    dc.description.AffiliationKarolina H. Markiewicz - Faculty of Chemistry, University of Bialystokpl
    dc.description.AffiliationKatarzyna Niemirowicz-Laskowska - Department of Experimental Pharmacology, Medical University of Bialystokpl
    dc.description.AffiliationMathias Destarac - Laboratoire IMRCP, CNRS UMR 5623, Paul Sabatier Universitypl
    dc.description.AffiliationPrzemysław Wielgat - Department of Clinical Pharmacology, Medical University of Bialystokpl
    dc.description.AffiliationIwona Misztalewska-Turkowicz - Faculty of Chemistry, University of Bialystokpl
    dc.description.AffiliationPaweł Misiak - − Faculty of Chemistry, University of Bialystokpl
    dc.description.AffiliationHalina Car - Department of Experimental Pharmacology, Medical University of Bialystokpl
    dc.description.AffiliationAgnieszka Z. Wilczewska - Faculty of Chemistry, University of Bialystokpl
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    dc.identifier.eissn1526-4602-
    dc.description.volume24pl
    dc.description.firstpage4854pl
    dc.description.lastpage4868pl
    dc.identifier.citation2Biomacromoleculespl
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