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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/16574
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    Pole DCWartośćJęzyk
    dc.contributor.authorMarkiewicz, Karolina Halina-
    dc.contributor.authorNiemirowicz-Laskowska, Katarzyna-
    dc.contributor.authorSzymczuk, Dawid-
    dc.contributor.authorMakarewicz, Kacper-
    dc.contributor.authorMisztalewska-Turkowicz, Iwona-
    dc.contributor.authorWielgat, Przemysław-
    dc.contributor.authorMajcher-Fitas, Anna M.-
    dc.contributor.authorMilewska, Sylwia-
    dc.contributor.authorCar, Halina-
    dc.contributor.authorWilczewska, Agnieszka Z.-
    dc.date.accessioned2024-05-28T10:43:38Z-
    dc.date.available2024-05-28T10:43:38Z-
    dc.date.issued2021-
    dc.identifier.citationInternational Journal of Molecular Sciences, Volume 22, Issue 9 (2021), p. 1-14pl
    dc.identifier.issn1422-0067-
    dc.identifier.urihttp://hdl.handle.net/11320/16574-
    dc.description.abstractOne of the promising strategies for improvement of cancer treatment is application of a combination therapy. The aim of this study was to investigate the anticancer activity of nanoformulations containing doxorubicin and iron oxide particles covered with polymeric shells bearing cholesterol moieties. It was postulated that due to high affinity to cell membranes, particles comprising poly(cholesteryl acrylate) can sensitize cancer cells to doxorubicin chemotherapy. The performed analyses revealed that the developed systems are effective against the human breast cancer cell lines MCF-7 and MDA-MB-231 even at low doses of the active compound applied (0.5 µM). Additionally, high compatibility and lack of toxicity of the tested materials against human red blood cells, immune (monocytic THP-1) cells, and cardiomyocyte H9C2(2-1) cells was demonstrated. Synergistic effects observed upon administration of doxorubicin with polymer–iron oxide hybrids comprising poly(cholesteryl acrylate) may provide an opportunity to limit toxicity of the drug and to improve its therapeutic efficiency at the same time.pl
    dc.description.sponsorshipThis work was financially supported by the National Science Center, Poland, grant No. NCN/2016/21/B/ST5/01365 (A.Z.W.). The analyses were performed in the Center of Synthesis and Analysis BioNanoTechno of the University of Bialystok. The equipment in the Center was funded by the EU as part of the Operational Program Development of Eastern Poland 2007–2013, projects POPW.01.03.00-20-034/09-00 and POPW.01.03.00-20-004/11.pl
    dc.language.isoenpl
    dc.publisherMDPIpl
    dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe*
    dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
    dc.subjectpolymer–iron oxide particlespl
    dc.subjectdoxorubicinpl
    dc.subjectanticancer activitypl
    dc.subjectcombination therapypl
    dc.titleMagnetic particles with polymeric shells bearing cholesterol moieties sensitize breast cancer cells to low dose of doxorubicinpl
    dc.typeArticlepl
    dc.rights.holder© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licensepl
    dc.identifier.doi10.3390/ijms22094898-
    dc.description.EmailKarolina H. Markiewicz: k.markiewicz@uwb.edu.plpl
    dc.description.EmailKatarzyna Niemirowicz-Laskowska: katarzyna.niemirowicz@umb.edu.plpl
    dc.description.EmailAgnieszka Z. Wilczewska: agawilcz@uwb.edu.plpl
    dc.description.AffiliationKarolina H. Markiewicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Polandpl
    dc.description.AffiliationKatarzyna Niemirowicz-Laskowska - Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Polandpl
    dc.description.AffiliationDawid Szymczuk - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Polandpl
    dc.description.AffiliationKacper Makarewicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Polandpl
    dc.description.AffiliationIwona Misztalewska-Turkowicz - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Polandpl
    dc.description.AffiliationPrzemysław Wielgat - Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Polandpl
    dc.description.AffiliationAnna M. Majcher-Fitas - Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30-348 Krakow, Polandpl
    dc.description.AffiliationSylwia Milewska - Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Polandpl
    dc.description.AffiliationHalina Car - Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna 37, 15-361 Bialystok, Polandpl
    dc.description.AffiliationAgnieszka Z. Wilczewska - Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1k, 15-245 Bialystok, Polandpl
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    dc.description.volume22pl
    dc.description.issue9pl
    dc.description.firstpage1pl
    dc.description.lastpage14pl
    dc.identifier.citation2International Journal of Molecular Sciencespl
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