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http://hdl.handle.net/11320/16573
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Pole DC | Wartość | Język |
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dc.contributor.author | Piktel, Ewelina | - |
dc.contributor.author | Markiewicz, Karolina H. | - |
dc.contributor.author | Wilczewska, Agnieszka Z. | - |
dc.contributor.author | Daniluk, Tamara | - |
dc.contributor.author | Chmielewska, Sylwia | - |
dc.contributor.author | Niemirowicz-Laskowska, Katarzyna | - |
dc.contributor.author | Mystkowska, Joanna | - |
dc.contributor.author | Paprocka, Paulina | - |
dc.contributor.author | Savage, Paul B. | - |
dc.contributor.author | Bucki, Robert | - |
dc.date.accessioned | 2024-05-28T10:34:50Z | - |
dc.date.available | 2024-05-28T10:34:50Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | International Journal of Nanomedicine, Volume 15 (2020), p. 4573-4589 | pl |
dc.identifier.issn | 1176-9114 (Print) | - |
dc.identifier.uri | http://hdl.handle.net/11320/16573 | - |
dc.description.abstract | Background: Therapeutic efficiency of ceragenins against cancers may be limited by lack of their hemocompatibility when high concentrations of molecules are required to reach a desired result. Synergistic effects observed upon administration of anticancer agents and metal nanoparticles may provide an opportunity to limit toxicity of immobilized ceragenins on the surface of metal nanoparticles and to improve their therapeutic efficiency at the same time. The aim of present work is to investigate the anticancer activities and hemocompatibility of nanoformulations consisting of ceragenin CSA-131 united with aminosilanemodified iron oxide-based magnetic nanoparticles (MNP) and prepared by 1) covalent bonding (MNP@CSA-131) or 2) by combining CSA-131 with MNP in 1:1 ratio (CSA-131 + MNP). Possible synergistic interactions between CSA-131 and magnetic nanoparticles were also quantified. | pl |
dc.description.abstract | Methods: MNP@CSA-131 and CSA-131+MNP were tested in vitro against selected lung and colon cancer cells using colorimetric, fluorimetric and flow cytometry methods. | pl |
dc.description.abstract | Results: Performed analysis demonstrates that MNP-based nanosystems significantly improve the killing efficiency of tested ceragenin, decreasing the viability of extra 1.37±4.72% to 76.07±15.30% cancer cells when compared to free CSA-131. Quantification of synergistic effects indicates the favorable interactions between CSA-131 and magnetic nanoparticles (CI < 1 for all tested doses), revealing at the same time a reduction in effective doses of ceragenin from 1.17 ±0.61 to 34.57 ± 12.78 times when combined with MNP. We demonstrate that both MNP@CSA131 and CSA-131+MNP induce significantly apoptosis of cancer cells and prevent the division of colon cancer cells even at relatively low doses of the active compound (10 µg/mL). Importantly, combining CSA-131 with MNP decreases the hemolytic activity of free ceragenin 4.72 to 7.88 times, which indicates a considerable improvement of hemotoxicity profile. | pl |
dc.description.abstract | Conclusion: Comparative analyses have revealed that both developed CSA-containing nanoformulations due to the utility of synergistic interactions between MNP and CSA-131, which are effective against lung and colon cancer cells. This indicates the new directions in preparation of MNP-based therapeutics, which are relatively easy to synthetize, costeffective and safe when intravenously administrated. | pl |
dc.description.sponsorship | This work was financially supported by grants from the National Science Centre, Poland (UMO-2015/19/N/NZ6/01872 to EP) and Medical University of Bialystok (SUB/1/DN/19/001/1162 to RB). Part of the study was conducted with the use of equipment purchased by the Medical University of Białystok as part of the RPOWP 2007-2013 funding, Priority I, Axis 1.1, contract No. UDA- RPPD.01.01.00-20-001/15-00 dated 26.06.2015. The synthesis and physicochemical analysis of magnetic nanoparticles and MNP-based compounds were performed in the Centre of Synthesis and Analysis BioNanoTechno of the University of Bialystok (POPW.01.03.00-20-034/09-00 and POPW.01.03.00-20-004/11 projects). This work was supported by the program of the Minister of Science and Higher Education under the name “Regional Initiative of Excellence in 2019-2022", project number: 024/RID/2018/19, financing amount: 11.999.000,00 PLN. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | pl |
dc.language.iso | en | pl |
dc.publisher | Dove Medical Press | pl |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe | * |
dc.rights | Uznanie autorstwa-Użycie niekomercyjne 4.0 Międzynarodowe | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | ceragenins | pl |
dc.subject | anticancer activity | pl |
dc.subject | colon cancer | pl |
dc.subject | lung cancer | pl |
dc.subject | synergistic effects | pl |
dc.subject | combinatory therapy | pl |
dc.title | Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells | pl |
dc.type | Article | pl |
dc.rights.holder | © 2020 Piktel et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). | pl |
dc.identifier.doi | 10.2147/IJN.S255170 | - |
dc.description.Email | Robert Bucki: buckirobert@gmail.com | pl |
dc.description.Affiliation | Ewelina Piktel - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Karolina H. Markiewicz - Faculty of Chemistry, University of Bialystok | pl |
dc.description.Affiliation | Agnieszka Z. Wilczewska - Faculty of Chemistry, University of Bialystok | pl |
dc.description.Affiliation | Tamara Daniluk - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Sylwia Chmielewska - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Katarzyna Niemirowicz-Laskowska - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Joanna Mystkowska - Department of Materials and Biomedical Engineering, Białystok University of Technology | pl |
dc.description.Affiliation | Paulina Paprocka - Department of Microbiology and Immunology, The Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce | pl |
dc.description.Affiliation | Paul B. Savage - Department of Chemistry and Biochemistry, Brigham Young University | pl |
dc.description.Affiliation | Robert Bucki - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok; Department of Microbiology and Immunology, The Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce | pl |
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dc.description.volume | 15 | pl |
dc.description.firstpage | 4573 | pl |
dc.description.lastpage | 4589 | pl |
dc.identifier.citation2 | International Journal of Nanomedicine | pl |
dc.identifier.orcid | 0000-0002-4531-7277 | - |
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dc.identifier.orcid | 0000-0002-3311-7147 | - |
dc.identifier.orcid | 0000-0002-3386-146X | - |
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dc.identifier.orcid | 0000-0002-4642-6109 | - |
dc.identifier.orcid | 0000-0001-7664-9226 | - |
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