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Pole DC | Wartość | Język |
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dc.contributor.author | Piktel, Ewelina | - |
dc.contributor.author | Wnorowska, Urszula | - |
dc.contributor.author | Cieśluk, Mateusz | - |
dc.contributor.author | Deptuła, Piotr | - |
dc.contributor.author | Prasad, Suhanya V. | - |
dc.contributor.author | Król, Grzegorz | - |
dc.contributor.author | Durnaś, Bonita | - |
dc.contributor.author | Namiot, Andrzej | - |
dc.contributor.author | Markiewicz, Karolina H. | - |
dc.contributor.author | Niemirowicz-Laskowska, Katarzyna | - |
dc.contributor.author | Wilczewska, Agnieszka Z. | - |
dc.contributor.author | Janmey, Paul A. | - |
dc.contributor.author | Reszeć, Joanna | - |
dc.contributor.author | Bucki, Robert | - |
dc.date.accessioned | 2024-05-28T09:45:11Z | - |
dc.date.available | 2024-05-28T09:45:11Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | International Journal of Molecular Sciences, Volume 21, Issue 7 (2020), p. 1-19 | pl |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/11320/16572 | - |
dc.description.abstract | Plasma gelsolin (pGSN) is a highly conserved abundant circulating protein, characterized by diverse immunomodulatory activities including macrophage activation and the ability to neutralize pro-inflammatory molecules produced by the host and pathogen. Using a murine model of Gram-negative sepsis initiated by the peritoneal instillation of Pseudomonas aeruginosa Xen 5, we observed a decrease in the tissue uptake of IRDye®800CW 2-deoxyglucose, an indicator of inflammation, and a decrease in bacterial growth from ascitic fluid in mice treated with intravenous recombinant human plasma gelsolin (pGSN) compared to the control vehicle. Pretreatment of the murine macrophage line RAW264.7 with pGSN, followed by addition of Pseudomonas aeruginosa Xen 5, resulted in a dose-dependent increase in the proportion of macrophages with internalized bacteria. This increased uptake was less pronounced when cells were pretreated with pGSN and then centrifuged to remove unbound pGSN before addition of bacteria to macrophages. These observations suggest that recombinant plasma gelsolin can modulate the inflammatory response while at the same time augmenting host antibacterial activity. | pl |
dc.description.sponsorship | This work was supported by the National Science Center, Poland under Grant: UMO-2015/17/B/NZ6/03473 (to RB), National Institutes of Health: GM111942 (to PAJ) and Medical University of Bialystok: SUB/1/DN/19/001/1162 (to RB), N/ST/MN/18/001/1162 (to MC). Part of the study was conducted with the use of equipment purchased by the Medical University of Białystok as part of the RPOWP 2007-2013 funding, Priority I, Axis 1.1, contract No. UDA- RPPD.01.01.00-20-001/15-00 dated 26.06.2015. This work was supported by the program of the Minister of Science and Higher Education under the name “Regional Initiative of Excellence in 2019–2022”, project number: 024/RID/2018/19, financing amount: 11.999.000,00 PLN. | pl |
dc.language.iso | en | pl |
dc.publisher | MDPI | pl |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe | * |
dc.rights | Uznanie autorstwa 4.0 Międzynarodowe | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | plasma gelsolin | pl |
dc.subject | inflammation | pl |
dc.subject | phagocytosis | pl |
dc.subject | sepsis | pl |
dc.subject | Pseudomonas aeruginosa | pl |
dc.title | Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice with Pseudomonas aeruginosa Sepsis | pl |
dc.type | Article | pl |
dc.rights.holder | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pl |
dc.identifier.doi | 10.3390/ijms21072551 | - |
dc.description.Email | Ewelina Piktel: ewelina.piktel@wp.pl | pl |
dc.description.Email | Urszula Wnorowska: u.wnorowska@gmail.com | pl |
dc.description.Email | Mateusz Cieśluk: mticv1@gmail.com | pl |
dc.description.Email | Piotr Deptuła: piotr.deptula@umb.edu.pl | pl |
dc.description.Email | Suhanya V. Prasad: suhanyavp@gmail.com | pl |
dc.description.Email | Grzegorz Król: g.krol@op.pl | pl |
dc.description.Email | Bonita Durnaś: bonita.durnas@onkol.kielce.pl | pl |
dc.description.Email | Andrzej Namiot: anamiot@poczta.onet.pl | pl |
dc.description.Email | Karolina H. Markiewicz: k.markiewicz@uwb.edu.pl | pl |
dc.description.Email | Katarzyna Niemirowicz-Laskowska: katia146@wp.pl | pl |
dc.description.Email | Agnieszka Z. Wilczewska: agawilczuwb@gmail.com | pl |
dc.description.Email | Paul A. Janmey: janmey@pennmedicine.upenn.edu | pl |
dc.description.Email | Joanna Reszeć: joannareszec@gmail.com | pl |
dc.description.Email | Robert Bucki: buckirobert@gmail.com | pl |
dc.description.Affiliation | Ewelina Piktel - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Urszula Wnorowska - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Mateusz Cieśluk - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Piotr Deptuła - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Suhanya V. Prasad - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Grzegorz Król - Department of Microbiology and Immunology, the Faculty of Medicine and Health Sciences of the Jan Kochanowski University in Kielce | pl |
dc.description.Affiliation | Bonita Durnaś - Department of Microbiology and Immunology, the Faculty of Medicine and Health Sciences of the Jan Kochanowski University in Kielce | pl |
dc.description.Affiliation | Andrzej Namiot - Department of Anatomy, Medical University of Bialystok | pl |
dc.description.Affiliation | Karolina H. Markiewicz - Institute of Chemistry, University of Białystok | pl |
dc.description.Affiliation | Katarzyna Niemirowicz-Laskowska - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok | pl |
dc.description.Affiliation | Agnieszka Z. Wilczewska - Institute of Chemistry, University of Białystok | pl |
dc.description.Affiliation | Paul A. Janmey - Institute for Medicine and Engineering, University of Pennsylvania | pl |
dc.description.Affiliation | Joanna Reszeć - Department of Pathology, Medical University of Bialystok | pl |
dc.description.Affiliation | Robert Bucki - Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok; Department of Microbiology and Immunology, the Faculty of Medicine and Health Sciences of the Jan Kochanowski University in Kielce | pl |
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dc.description.volume | 21 | pl |
dc.description.issue | 7 | pl |
dc.description.firstpage | 1 | pl |
dc.description.lastpage | 19 | pl |
dc.identifier.citation2 | International Journal of Molecular Sciences | pl |
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