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    • Proszę używać tego identyfikatora do cytowań lub wstaw link do tej pozycji: http://hdl.handle.net/11320/15813
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    Pole DCWartośćJęzyk
    dc.contributor.authorHeropolitańska-Pliszka, Edyta-
    dc.contributor.authorBerk, Klaudia-
    dc.contributor.authorMaciejczyk, Mateusz-
    dc.contributor.authorSawicka-Powierza, Jolanta-
    dc.contributor.authorBernatowska, Ewa-
    dc.contributor.authorWolska-Kuśnierz, Beata-
    dc.contributor.authorPac, Małgorzata-
    dc.contributor.authorDąbrowska-Leonik, Nel-
    dc.contributor.authorPiatosa, Barbara-
    dc.contributor.authorLewandowicz-Uszyńska, Aleksandra-
    dc.contributor.authorKarpińska, Joanna-
    dc.contributor.authorZalewska, Anna-
    dc.contributor.authorMikołuć, Bożena-
    dc.date.accessioned2024-01-22T14:05:14Z-
    dc.date.available2024-01-22T14:05:14Z-
    dc.date.issued2020-
    dc.identifier.citationJournal of Clinical Medicine, Volume 9, Issue 5, 2020, pp. 1-14pl
    dc.identifier.issn2077-0383-
    dc.identifier.urihttp://hdl.handle.net/11320/15813-
    dc.description.abstractThe aim of our study was to evaluate redox status, enzymatic and non-enzymatic antioxidant barriers, oxidative damage of proteins, lipids and DNA, as well as concentration of coenzyme Q10 and vitamins A and E in patients with chronic granulomatous disease (CGD). The study was performed on fifteen Caucasian individuals (median age 24 years and seven months) diagnosed with CGD. The mutation in the NCF1 gene was confirmed in ten patients, and in the CYBB gene in five patients. We demonstrated high levels of total oxidant status (TOS) and oxidative stress index (OSI), lipids (↑8-isoprostanes (8-isoP), ↑4-hydroxynonenal (4-HNE)), proteins (↑advanced oxidation protein products (AOPP)) and DNA (↑8-hydroxy-2′-deoxyguanosine (8-OHdG)) oxidation products in CGD individuals as compared to sex- and age-matched healthy controls. We showed enhanced serum enzymatic activity of catalase (CAT) and superoxide dismutase-1 (SOD) and significantly decreased coenzyme Q10 concentration. Our study confirmed redox disturbances and increased oxidative damage in CGD patients, and indicated the need to compare redox imbalance depending on the type of mutation and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. The question regarding effectiveness of antioxidant therapy in patients with CGD is open, and the need to establish guidelines in this area remains to be addressed.pl
    dc.description.sponsorshipThis work was supported by grants from the Medical University of Bialystok, Poland (grant number: SUB/1/DN/19/002/1126).pl
    dc.language.isoenpl
    dc.publisherMDPIpl
    dc.rightsCreative Commons Attribution (CC BY) license*
    dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
    dc.subjectchronic granulomatous diseasepl
    dc.subjectprimary immunodeficiencypl
    dc.subjectoxidative stresspl
    dc.subjectantioxidantspl
    dc.subjectcoenzyme Q10pl
    dc.titleSystemic Redox Imbalance in Patients with Chronic Granulomatous Diseasepl
    dc.typeArticlepl
    dc.rights.holder© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)pl
    dc.identifier.doi10.3390/jcm9051397-
    dc.description.EmailJoanna Karpińska: joasia@uwb.edu.plpl
    dc.description.AffiliationEdyta Heropolitańska-Pliszka - Clinical Immunology the Children’s Memorial Health Institute, al. Dzieci Polskich 20, 04-730 Warsaw, Polandpl
    dc.description.AffiliationKlaudia Berk - Department of Physiology, Medical University of Bialystok, ul. Mickiewicza 2c, 15-233 Bialystok, Polandpl
    dc.description.AffiliationMateusz Maciejczyk - Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, ul. Mickiewicza 2c, 15-233 Bialystok, Polandpl
    dc.description.AffiliationJolanta Sawicka-Powierza - Department of Family Medicine, Medical University of Bialystok, 15-054 Bialystok, Polandpl
    dc.description.AffiliationEwa Bernatowska - Clinical Immunology the Children’s Memorial Health Institute, al. Dzieci Polskich 20, 04-730 Warsaw, Polandpl
    dc.description.AffiliationBeata Wolska-Kuśnierz - Clinical Immunology the Children’s Memorial Health Institute, al. Dzieci Polskich 20, 04-730 Warsaw, Polandpl
    dc.description.AffiliationMałgorzata Pac - Clinical Immunology the Children’s Memorial Health Institute, al. Dzieci Polskich 20, 04-730 Warsaw, Polandpl
    dc.description.AffiliationNel Dąbrowska-Leonik - Clinical Immunology the Children’s Memorial Health Institute, al. Dzieci Polskich 20, 04-730 Warsaw, Polandpl
    dc.description.AffiliationBarbara Piatosa - Histocompatibility Laboratory, Children’s Memorial Health Institute, al. Dzieci Polskich 20, 04-730 Warsaw, Polandpl
    dc.description.AffiliationAleksandra Lewandowicz-Uszyńska - 3rd Department and Clinic of Pediatrics, Immunology and Rheumatology of Developmental Age, Wroclaw Medical University, ul. Koszarowa 5, 50-367 Wrocław, Polandpl
    dc.description.AffiliationJoanna Karpińska - Institute of Chemistry, University of Bialystok, ul. Ciołkowskiego. 1K, 15-245 Białystok, Polandpl
    dc.description.AffiliationAnna Zalewska - Experimental Dentistry Laboratory, Medical University of Bialystok, ul. Szpitalna 37, 15-295 Bialystok, Polandpl
    dc.description.AffiliationBożena Mikołuć - Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Waszyngtona 17, 15-274 Bialystok, Polandpl
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    dc.description.volume9pl
    dc.description.issue5pl
    dc.description.firstpage1pl
    dc.description.lastpage14pl
    dc.identifier.citation2Journal of Clinical Medicinepl
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